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EC number: 203-149-1
CAS number: 103-83-3
In a Guinea PigMaximization Test according to OECD TG 400 (Magnusson and
Klingman) male guinea pigs were tested with following concentrations of
the test substance:
1st application: Induction 2.5 % intracutaneous
2nd application: Induction 12 % occlusive epicutaneous
3rd application: Challenge 6 % and 3% occlusive epicutaneous
The test substance was formulated as an emulsion with Cremophor EL in
sterile physiological saline solution (2% V/V).
No skin reddening was observed after the provocation with 6% and 3% of
test substance neither in the test animals nor in the control animals.
The test substance therefore shows no skin sensitating potential (Bayer
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