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EC number: 203-149-1
CAS number: 103-83-3
There are subacute oral toxicity studies available in rats dosed with
N,N-Dimethylbenzylamine up to 400 mg/kg bw/day by gavage for 28 days
resulting in a NOAEL of 150 mg/kg bw/day.
A study according to OECD TG 408 (rat, oral) and GLP is planned after
the approval by ECHA.
The data were processed, where appropriate, to give group mean values
and standard deviations. The nature of the data was considered to be
such that statistical analysis would not have provided additional
In an test according to OECD TG 407 and GLP groups of male and female
Crl:CD(SD)BR rats received N,N-Dimethylbenzylamine in corn oil by daily
oral gavage at nominal dose levels of 6, 30 or 150 mg/kg bw/day. A
further group of the same size received corn oil alone and served as
control. There were no major differences between control and treated
rats. The high dose group males had slightly higher testis weights than
the controls. However there was no histopathological correlate.
Therefore this finding was considered not to be of toxicological
relvance. The NOAEL was determined to be 150 mg/kg bw/day (BG Chemie
There is no sub-chronic study available. In accordance with section 1 of
REACH Annex XI, a sub-chronic repeated dose toxicity study is not
There are 2 sub-acute oral studies available which are performed
according the respective guideline and in which the test substance
was applied by gavage to male and female rats in dosages of 0, 6, 30,
150, 200 mg/kg bw/day (BG Chemie 1988, 1990) or 0, 50, 100, 200, 400
mg/kg bw/day (MHLW 1997), respectively. In addition, rats of the control
group and rats treated with 200 and 400 mg/kg bw/day were observed after
termination of treatment for further 2 weeks (recovery group, MHLW 1997).
Mortalities of both males and females receiving 400 mg/kg were observed
from week 2. Miosis and salivation was observed in those rats receiving
200 and 400 mg/kg bw/day. The 150 mg/kg bw/day males had slightly higher
testis weights than the controls. However, there was no
histopathological correlate. In male and female animals dosed with 100
mg/kg bw/day miosis was the only observed finding . There were no
differences between controls and male and female rats dosed with 50, 30
or 6 mg/kg bw/day. Thus, the overall NOAEL is considered to be 150 mg/kg
There are no data available
There are no valid studies available
Based on the available data, no classification is required according to
the classification criteria 67/548/EWG and EU Regulation 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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