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EC number: 203-149-1 | CAS number: 103-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline test and GLP
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 989
- Reference Type:
- publication
- Title:
- Mutagenitätsprüfungen von Arbeitsstoffen mit wesentlicher Bedeutung und Verbreitung
- Author:
- Heimann K.-G- et al.
- Year:
- 1 998
- Bibliographic source:
- GUM 4/89
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- - preincubation method
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Benzyldimethylamine
- EC Number:
- 203-149-1
- EC Name:
- Benzyldimethylamine
- Cas Number:
- 103-83-3
- Molecular formula:
- C9H13N
- IUPAC Name:
- benzyldimethylamine
- Details on test material:
- N,N-dimethylbenzylamin, purity: 99.34 %
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimuriun TA98. TA100. TA1535, TA1537, TA1538
- Additional strain / cell type characteristics:
- other: Salmonella typhimuriun TA98. TA10,. TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix of male Wistar rat liver after induction with Aroclor 1254
- Test concentrations with justification for top dose:
- 0 - 1.58 - 5 - 15.8 - 50 - 158 -500 -1580 - 5000 µg/plate
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: Methyl methansulfonatem 9-Aminoacridine, 2-Nitrofluorene, N-ethyl-Nnitro-N.nitrosoguanidine, 2-Aminoanthracene, Benzo(a)pyrene
- Details on test system and experimental conditions:
- IUCLID4 Type: Ames test, according to the respective guieline: preincubation procedere
- Evaluation criteria:
- A material is identified as a mutagen in this test system if ther was a reproducible demonstration of a dose-effect relation with a 2-fold increase in the number of revertants compared with the concurrent negative control in at least 1 strain. With the strain TA100 a 1.5-fold increase was the criterion for a positive result.
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimuriun TA98. TA100. TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- +/- S9-mix: at 5000 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: other: TA 98, TA 100, TA 1535, TA 1537, TA 1538
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- negative
- Executive summary:
N,N-Dimethylbenzylamine diluted in DMSO was tested for point mutations in the Ames-test according to OECD TG 471 and GLP using Salmonella typhimuriun TA98, TA100, TA1535, TA1537, TA1538 in the presence and in the absence of a metabolic activation system and concentrations ranging between 1.58 and 5000 µg/plate. Cytotoxicity was observed at the highest test concentration. Under the conditions of this test N,N-dimethylbenzylamine did not induce point mutations (BG Chemie 1986).
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