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EC number: 203-149-1
CAS number: 103-83-3
RS-Freetext:Mortality:Dose % Time after appl.low 20 1.5 hmedium 100 7-20 minhigh 100 10-20 minLD50 = 0.65 ml/kg bw (0.48-0.88 ml/kg bw)= 579 mg/kg bw Signs of toxicity: Tremors, salivation, death within few minutes to 1.5 h.Gross necropsy findings:Dead animals: congestion in stomach and intestines,hemorrhages in stomachSurvivors: no abnormal findings
In an acute oral toxicity study undiluted test material was administered
by gavage to groups of 5 male Wistar-derived rats of 90-120 g and 3-4
weeks of age. Following doses were tested: 0.5 , 1.0, 2.0 ml/kg bw (445,
890, 1780 mg/kg bw) Animals were observed daily for signs of toxicity
over a 14-day postdosing period, at the end they were subjected to gross
pathological examination. All animals died at a dose of 2.0 and 1.0
ml/kg bw, but only 1 of 5 at 0.5 ml/kg, indicating a steep slope to the
response. Deaths occurred within 10 to 90 minutes after dosing, with the
latency increasing as dosage decreased. Signs of toxicity included
tremors and salivation which were seen within a few minutes after
dosing. Autopsy examination of dead animals showed congestion and
hemorrhages of the stomach, and intestinal congestion. Survivors of the
0.5 ml/kg bw group, sacrificed at the end of the 14 -day postdosing
observation period, showed no gross abnormalities at autopsy. The LD50
was 0.65 ml/kg bw (resp. 579 mg/kg bw, Ballantyne1985).
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