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EC number: 203-149-1
CAS number: 103-83-3
Different doses of undiluted test substance given per gavage to male rats resulted in LD50 oral: 0.65 ml (579 mg/kg bw);Different doses applied to the dorsal skin of male rabbits resulted in LD50 dermal: 1.66 ml/kg (1477 mg/kg bw);Whole body exposure of male and femle rats to different vapour concentrations for 4 hours resulted in LC50 inhal: 373 ppm (2052 mg/m³).
ACUTE ORAL TOXICITY
In an acute oral toxicity study undiluted test material was administered
by gavage to groups of 5 male Wistar-derived rats of 90-120 g and 3-4
weeks of age. Following doses were tested: 0.5 , 1.0, 2.0 ml/kg bw (445,
890, 1780 mg/kg bw) Animals were observed daily for signs of toxicity
over a 14-day postdosing period, at the end they were subjected to gross
pathological examination. All animals died at a dose of 2.0 and 1.0
ml/kg bw, but only 1 of 5 at 0.5 ml/kg, indicating a steep slope to the
response. Deaths occurred within 10 to 90 minutes after dosing, with the
latency increasing as dosage decreased. Signs of toxicity included
tremors and salivation which were seen within a few minutes after
dosing. Autopsy examination of dead animals showed congestion and
hemorrhages of the stomach, and intestinal congestion. Survivors of the
0.5 ml/kg bw group, sacrificed at the end of the 14 -day postdosing
observation period, showed no gross abnormalities at autopsy. The LD50
was 0.65 ml/kg bw (resp. 579 mg/kg bw, Ballantyne1985).
ACUTE INHALATION TOXICITY
The acute inhalation toxicity of the test substance was studied in
groups of 6 male and 6 female F344 rats per concentration
by 4-hours exposures to 25, 150, 277, 500 ppm (133, 769, 1532, 2771
mg/m³). A control group (2/sex) was exposed to filtered air only.
Mortalities occurred at the highest concentration only, with all animals
dying within 2 to 2.5 hours from the start of the exposure. Signs of
toxicity included irritation, salivation labored breathing and
urogenital wetness. During the 14 day postexposure, periorbital and
perinasal red encrustations were observed and pathological changes
determined in lungs and the upper respiratory tract at 500 and 277 ppm.
The LC50 was determined to be 373 ppm/4h (2052 mg/m³/4h, Ballantyne 1985)
ACUTE DERMAL TOXICITY
In an acute dermal toxicity study the undiluted test substance was
applied to the clipped dorsal skin of groups containing 4 male
rabbits/group at doses of 0.5, 1.0, 1.4, 2.0 ml/kg bw. The test material
was maintained in contact with the skin by a polythene sheet held in
place with an adhesive dressing. Animals were immobilized during a 24-hr
occlusion period. At the end of the contact period the polythene
sheeting was removed, the skin gently wiped clean, and the area
inspected for signs of local inflamation. Animals were observed daily
over a 14-day postapplication period for signs of toxicity. At the end
of this time the survivors were sacrificed and subjected to autopsy
examination. All animals died at the highest dose of 2.0 ml/kg bw, with
a latency of up to 2 days. Signs of toxicity included tremors and
hyperactivity. No signs of systemic toxicity were seen in animals
following the application of 1.4 ml/kg bw and lower. On removal of the
occlusive dressing, edema and necrosis were seen at the site of
application of undiluted test substance to skin. This progressed to scab
formation over the ensuing 14 days. Autopsy examination of the animals
that died revealed a red mottled appearance to the liver and kidneys,
but otherwise there were no abnormalities. The LD50 was determined to be
1.66 ml/kg bw (ca1477 mg/kg bw).
According to the classification criteria in Regulation 67/548/EWG , and
according to Regulation (EC) 1272/2008 (CLP/GHS) N,N-Dimethylbenzylamine
is already classified and labelled: R20/21/22, :respectively
acute oral toxicity: category 4 (H302); acute dermal toxicty: category 4
(H312); acute inhalation toxicity: category 4 (H332).
However, based on the available data on acute inhalation toxicity,
regarding Regulation (EC) 1272/2008 (CLP/GHS), classification in
category 3 (acute inhalation toxicity) and labelling with H331 is
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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