Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Type of method:
other: no data
Partition coefficient type:
Key result
log Pow
Partition coefficient:
Remarks on result:
other: no data on temperature available

only neutral form measured, no data on temperature

Executive summary:

Benzyldimethylamine has a log Pow of 1.98 (Hansch, 1995).

Description of key information

N,N-dimethylbenzylamine has an experimentally determined log Kow of 1.98 under its non-ionised form at pH13 (Hansch, 1995).

Low potential for bioaccumulation (based on CLP cut-off value for aquatic chronic toxicity: logKow <4)

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
25 °C

Additional information

Five reliable literature data sources were identified, and provide consistent logKow values, ranging between 1,54 and 1,98. However, in most of them, the information of pH was missing, so they were regarded as Supporting data only, due to pKa falling into the environmentally-relevant pH range (pKa = 8,9; see IUCLID section 4.21).

Hansch (1995) was selected as Key, as specified to be experimentally determined, at a pH of 13, therefore corresponding to the non-ionised form, according to logKow definition. It is also the highest, therefore worst-case value.

The magnitude of order for the non-ionised form was confirmed by QSAR prediction (BFS, 2023), but as the result was lower than in the publication from Hansch, it was kept as Supporting too.

It should be highlighted that this strategy answers regulatory requirements (i.e. logKow corresponding to the non-ionised form).