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EC number: 203-149-1
CAS number: 103-83-3
RS-Freetext:Signs of toxicity (time after start of exp.):irritation (1.5 h), excess salivation, labored breathing, urogenital wetness,
red periorbital and perinasal incrustations at concentrations of 769 mg/m³ and
higherBody weight (before and 1,3,6,14 d after exp.):No significant decrease in surviving animalsMortality:All animals of the highest dose group died within 1 day.LC50 = 2052mg/m³ (1720-2472)Gross necropsy:Red patchy discoloration of lungs in dead animals. No abnormal findings in
survivors.Microscopic examination of respiratory tract:2771 mg/m³: pulmonary congestion and epithelial vacuolisation and necrosis of
nasal mucosa in both males and females1532 mg/m³: pulmonary congestion in males and females; acute inflammation in
the nasal mucosa in male rats. Lower doses: no abnormal findings
The acute inhalation toxicity of the test substance was studied in
groups of 6 male and 6 female F344 rats per concentration
by 4-hours exposures to 25, 150, 277, 500 ppm (133, 769, 1532, 2771
mg/m³). A control group (2/sex) was exposed to filtered air only.
Mortalities occurred at the highest concentration only, with all animals
dying within 2 to 2.5 hours from the start of the exposure. Signs of
toxicity included irritation, salivation labored breathing and
urogenital wetness. During the 14 day postexposure, periorbital and
perinasal red encrustations were observed and pathol. changes determined
in lungs and the upper resp tract at 500 and 277 ppm
The LC50 was determined to be 373 ppm/4h (2052 mg/m³/4h, Ballantyne 1985)
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