Registration Dossier
Registration Dossier
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EC number: 203-149-1 | CAS number: 103-83-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a Guinea Pig Maximization Test according to OECD TG 406 (Magnusson and Klingman) male guinea pigs were tested with following concentrations of the test substance:
1st application: Induction 2.5 % intracutaneous
2nd application: Induction 12 % occlusive epicutaneous
3rd application: Challenge 6 % and 3% occlusive epicutaneous
The test substance was formulated as an emulsion with Cremophor EL in sterile physiological saline solution (2% V/V).
No skin reddening was observed after the provocation with 6% and 3% of test substance neither in the test animals nor in the control animals. The test substance therefore shows no skin sensitisation potential (Bayer AG 1993).
Migrated from Short description of key information:
The test substance shows no skin sensitisation potential.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data
Justification for classification or non-classification
Skin Sensitization
Based on the available data, no classification is required according to the classification criteria 67/548/EWG and
EU Regulation 1272/2008 (CLP/GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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