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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

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Description of key information

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Additional information

Six healthy male volunteers were exposed for 8 h to DMBA at air levels of 20, 45, and 80 µm/m³. Air levels of DMBA were analyzed by gas chromatography (GC). The total urinary amount of DMBA (U-SumDMBA; DMBA and metabolites that can be reduced to DMBA, e.g., N,N-Dimethylbenzylamin-N-oxide) was analyzed using GC-mass spectrometry (MS). The exposure chamber maintained very low (0 -130 µg/m³) and steady concentrations for several weeks. DMBA uptake by inhalation was 76%. The amine was quickly distributed and biotransformed to nearly 100%. DMBA was eliminated in the urine with a half-time of 4.3 h. More than 50% was eliminated within 2 h of exposure (Stahlbom, 1997).

The detection limit for DMBA in air for a 60-l air sample collected in 10 ml absorption solution was 2 µg/m³ and in charcoal tubes, 0.3 µg/m³. The detection limit for DMBA in urine was 0.02 mg/l. Ten male workers manufacturing epoxy resin were monitored during a full shift in the working environment and urine samples were collected at the end of exposure. The mean exposure and the highest DMBA concentration observed in air were 18 µg/m³ (time-weighted average: range 3 - 48 µg/m³) and 91 µg/m³, respectively. The DMBA concentrations in the urine samples were below the detection limit. After reduction of the urine samples the DMBA concentrations (U-SumDMBA) ranged from 0.02 to 0.22 mg/l. There was significant correlation between the exposure to DMBA and the U-SumDMBA. This observation suggests that the U-SumDMBA in urine samples collected at the end of a shift is a useful indicator of occupational exposure to DMBA (Stahlbom, 1995).