Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-149-1
CAS number: 103-83-3
Six healthy male volunteers were exposed for 8 h to DMBA at air levels
of 20, 45, and 80 µm/m³. Air levels of DMBA were analyzed by gas
chromatography (GC). The total urinary amount of DMBA (U-SumDMBA; DMBA
and metabolites that can be reduced to DMBA, e.g.,
N,N-Dimethylbenzylamin-N-oxide) was analyzed using GC-mass spectrometry
(MS). The exposure chamber maintained very low (0 -130 µg/m³) and steady
concentrations for several weeks. DMBA uptake by inhalation was 76%. The
amine was quickly distributed and biotransformed to nearly 100%. DMBA
was eliminated in the urine with a half-time of 4.3 h. More than 50% was
eliminated within 2 h of exposure (Stahlbom, 1997).
The detection limit for DMBA in air for a 60-l air sample collected in
10 ml absorption solution was 2 µg/m³ and in charcoal tubes, 0.3 µg/m³.
The detection limit for DMBA in urine was 0.02 mg/l. Ten male workers
manufacturing epoxy resin were monitored during a full shift in the
working environment and urine samples were collected at the end of
exposure. The mean exposure and the highest DMBA concentration observed
in air were 18 µg/m³ (time-weighted average: range 3 - 48 µg/m³) and 91
µg/m³, respectively. The DMBA concentrations in the urine samples were
below the detection limit. After reduction of the urine samples the DMBA
concentrations (U-SumDMBA) ranged from 0.02 to 0.22 mg/l. There was
significant correlation between the exposure to DMBA and the U-SumDMBA.
This observation suggests that the U-SumDMBA in urine samples collected
at the end of a shift is a useful indicator of occupational exposure to
DMBA (Stahlbom, 1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again