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EC number: 204-427-5 | CAS number: 120-80-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The purity of the test substance is not known.
Data source
Reference
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone: a review of the industrial toxicology and current industrial exposure limits.
- Author:
- Flickinger C.W.
- Year:
- 1 976
- Bibliographic source:
- American Industrial Hygiene Association Journal, 37(10), 596-606.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize test
- Deviations:
- not specified
- Principles of method if other than guideline:
- Federal register (1961) pp.7333-7341, Part 191- Hazardous Substances: definitions and Procedural and Interpretative Regulations, Final Order .
- GLP compliance:
- no
Test material
- Reference substance name:
- Pyrocatechol
- EC Number:
- 204-427-5
- EC Name:
- Pyrocatechol
- Cas Number:
- 120-80-9
- Molecular formula:
- C6H6O2
- IUPAC Name:
- pyrocatechol
- Details on test material:
- Koppers Company, Inc, Catechol C.P. Crystal Lot 68-1.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- - Sex: male
- Age: Unknown
No more data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount: 0.1 g
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- The resultant total eye irritation score were evaluated after 24, 48 and 72 hours.
No more data.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- other: Total eye irritation evaluation
- Time point:
- 24/48/72 h
- Score:
- 78 - 103
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- other: No individual data.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for cornea opacity has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for iris has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for conjunctivae has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for chemosis has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritant / corrosive response data:
- - 24 h (score = 103): following exposure showed a diffuse deep-crimson red conjunctivitis with individual vessels not easily discernible, swelling with the lids half closed, severe discharge, iritis, and dense corneal opacities in all of the six exposed eyes.
- 48 h (score = 85): the treated eyes remained relatively unchanged.
- 72 h (score = 78): severe conjunctivitis, iritis and diffuse corneal opacities persisted in all of the exposed eyes.
-14 d: all the treated eyes revealed pannus formations and keratoconnus.
- No information regarding the reversibility within 21 days. - Other effects:
- Upon application, the conjunctivae became moderately erythematous and oedematous, and moderate exudate and corneal opacity were produced. Signs of marked discomfort were evident and the effects are not fully reversible within 14 days. No information regarding the reversibility within 21 days.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Based on the results and since there is no reversibility.
- Conclusions:
Catechol causes serious eye damage in EU GHS.- Executive summary:
In a primary eye irritation study (Flickinger, 1976), 0.1 mg of Catechol was instilled into the conjunctival sac of one eye of 6 male albino rabbits. Animals then were observed for 14 days. Irritation was scored by the method of Draize.
Upon application, the conjunctivae became moderately erythematous and oedematous, and moderate exudate and corneal opacity were produced. Signs of marked discomfort were evident. After 14 days of observation, all the treated eyes revealed pannus formations and keratoconnus.
The total evaluation varied from 103 to 78 at 24 to 72 hours.
Based on these results, Catechol causes serious damage to eyes.
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