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EC number: 204-427-5
CAS number: 120-80-9
Catechol never induced an observable sensitivity to less
than 0.2 µmole with a geometric mean of 3.2 µmoles.
a dermal sensitization study (Baer et al., 1967) with Catechol,
8 to 12 Hartley guinea pigs were tested using a modified method of
Freund's complete adjuvant test.
Sensitisation was carried out by injection of an emulsion
in complete Freund's adjuvant, at weekly intervals,
successively into the nuchal area, the inguinal-axillary
region and the foot pads.
Animals were given a skin test (topical application of
catechol in acetone) 4 weeks after the last sensitising
injection and then given two repetitive tests at 2-weeks intervals.
In this study,
Catechol was used as inducer of sensitization and gave the appropriate
response as “sensitizing”.
considered as a skin sensitizer in this study.
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