Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-427-5 | CAS number: 120-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Catechol was found irritating to skin and inducing severe dammage to eyes in Draize tests.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- The purity of the test substance is unknown. Exposure duration was 24 h instead of 4 h. Observations were evaluated according to the scoring of Draize.
- Qualifier:
- according to guideline
- Guideline:
- other: Draize test
- Deviations:
- not specified
- Principles of method if other than guideline:
- Federal register (1961) pp.7333-7341, Part 191- Hazardous Substances: definitions and Procedural and Interpretative Regulations, Final Order. Scoring performed according to Draize.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mg of catechol on bellies of rabbits.
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 14 days
- Number of animals:
- 6
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 5.5
- Max. score:
- 32
- Reversibility:
- other: see results
- Remarks on result:
- other: The result is the mean 24/72h (no data available at 48h).
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.95
- Reversibility:
- other: see results
- Remarks on result:
- other: The result is the mean 24/72h (no data available at 48h).
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Reversibility:
- other: see results
- Remarks on result:
- other: The result is the mean 24/72h (no data available at 48h).
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: No individual data is available.
- Irritant / corrosive response data:
- - Intact skin:
The contact of catechol produced slight to moderate erythema (score 2.2) and slight oedema (score 1.2) after 24 h.
The irritation was less marked 72 h after exposure (erythema: 1.7 and oedema: 1.0) .
After 14 days, the intact areas were free of irritation.
- Abraded skin:
The contact of catechol produced necrosis after 24 h. After 14 days, the necrotic areas were incrusted and beginning to slough. - Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
Catechol causes skin irritation in EU GHS.- Executive summary:
In a primary dermal irritation study (Flickinger, 1976), 6 albino rabbits were dermally exposed to 0.5 mg of Catechol for 24 hours to bellies. No indication was done concerning dressing. Skin of animals was abraded or intact. Animals then were observed for 14 days. Irritation was scored by the method of Draize.
The contact of catechol produced slight to moderate erythema (score 2.2) and slight oedema (score 1.2) after 24 hours on intact skin.
The irritation was less marked 72 h after exposure (erythema: 1.7 and oedema: 1.0).
In this study, Catechol is irritating to the skin based on Draize scoring.
Reference
Primary Irritation scores, Intact and abraded skin on rabbits (0.5 g, 24h period):
|
Erythema |
Edema |
||
|
Intact |
Abraded |
Intact |
Abraded |
24 hours |
2.2 |
4 |
1.2 |
4 |
72 hours |
1.7 |
4 |
1 |
4 |
Total |
3.9 |
8 |
2.2 |
8 |
Primary Irritation score: 5.5
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The purity of the test substance is not known.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize test
- Deviations:
- not specified
- Principles of method if other than guideline:
- Federal register (1961) pp.7333-7341, Part 191- Hazardous Substances: definitions and Procedural and Interpretative Regulations, Final Order .
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- - Sex: male
- Age: Unknown
No more data - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount: 0.1 g
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- The resultant total eye irritation score were evaluated after 24, 48 and 72 hours.
No more data. - Irritation parameter:
- overall irritation score
- Basis:
- other: Total eye irritation evaluation
- Time point:
- 24/48/72 h
- Score:
- 78 - 103
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- other: No individual data.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for cornea opacity has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for iris has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for conjunctivae has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- other: No score for chemosis has been given. Only the overall irritation score is provided since the study was performed in 1976.
- Irritant / corrosive response data:
- - 24 h (score = 103): following exposure showed a diffuse deep-crimson red conjunctivitis with individual vessels not easily discernible, swelling with the lids half closed, severe discharge, iritis, and dense corneal opacities in all of the six exposed eyes.
- 48 h (score = 85): the treated eyes remained relatively unchanged.
- 72 h (score = 78): severe conjunctivitis, iritis and diffuse corneal opacities persisted in all of the exposed eyes.
-14 d: all the treated eyes revealed pannus formations and keratoconnus.
- No information regarding the reversibility within 21 days. - Other effects:
- Upon application, the conjunctivae became moderately erythematous and oedematous, and moderate exudate and corneal opacity were produced. Signs of marked discomfort were evident and the effects are not fully reversible within 14 days. No information regarding the reversibility within 21 days.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Based on the results and since there is no reversibility.
- Conclusions:
- Catechol causes serious eye damage in EU GHS.
- Executive summary:
In a primary eye irritation study (Flickinger, 1976), 0.1 mg of Catechol was instilled into the conjunctival sac of one eye of 6 male albino rabbits. Animals then were observed for 14 days. Irritation was scored by the method of Draize.
Upon application, the conjunctivae became moderately erythematous and oedematous, and moderate exudate and corneal opacity were produced. Signs of marked discomfort were evident. After 14 days of observation, all the treated eyes revealed pannus formations and keratoconnus.
The total evaluation varied from 103 to 78 at 24 to 72 hours.
Based on these results, Catechol causes serious damage to eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Skin irritation:
Two studies were available. One of them was selected as key study and had reliability 2, the other one was selected as supporting study and had reliability 3. The summary of the key study is the following:
In a primary dermal irritation study (Flickinger, 1976), 6 albino rabbits were exposed by dermal route to 0.5 mg of catechol for 24 hours to bellies. No indication was done concerning dressing. Skin of animals was abraded or intact. Animals then were observed for 14 days. Irritation was scored by the method of Draize. The contact of catechol produced slight to moderate erythema (score 2.2) and slight oedema (score 1.2) after 24 hours on intact skin. The irritation was less marked 72 h after exposure (erythema: 1.7 and oedema: 1.0).
Eye irritation:
Only one study was available and was selected as key study and had reliability 2. The summary of this key study is the following:
In a primary eye irritation study (Flickinger, 1976), 0.1 mg of Catechol was instilled into the conjunctive sac of one eye of 6 male albino rabbits. Animals then were observed for 14 days. Irritation was scored by the method of Draize. Upon application, the conjunctivae became moderately erythematous and oedematous, and moderate exudate and corneal opacity were produced. Signs of marked discomfort were evident. The total evaluation varied from 103 to 78 at 24 to 72 hours.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating/severe dammage
Justification for classification or non-classification
Catechol is irritating to the skin based on Draize scoring. According to classification criteria of EC regulation 1272/2008 and current EC regulation in Annex VI, table 3 (13th ATP), the catechol is classified as irritant for the skin category 2 (H315: Causes skin irritation)
Catechol is highly irritating to eyes, based on the study available. In the current EC regulation in Annex VI, table 3 (13th ATP), the catechol is classified as irritant for the eye category 2 (H319: Causes serious eye irritation) but it should be classified as eye category 1 (H318: Causes serious eye damage) based on the available data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
