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EC number: 204-427-5
CAS number: 120-80-9
Short-term toxicity to fish
Seven studies were
available, and one of them (Geiger et al., 1990) was selected as key
study. In this
96-hour acute toxicity study, Pimephales promelas were exposed to
nominal concentrations of 0, 8, 10, 12.5, 15.6 and 19.5 mg/L under flow
through conditions, and mortality was recorded. The
96-h LC50 was 9.22
is toxic for Pimephales promelas under the tested conditions. The
toxicity study is classified as acceptable and satisfies the guideline
requirements for acute fish toxicity study.
other reliable studies gave results in the same range as the key study
and were considered supporting studies. The
other available studies had a reliability 3 or 4.
Long-term toxicity to fish
No data on long-term toxicity to fish is
Short-term toxicity to aquatic
study which was done according to GLP and following the OECD Guideline
is available (Seeland-Fremer et al., 2014). The study was done in closed
systems and analytical measurements were performed and a Klimisch rating
of 1 was assigned to this study. This study resulted in an EC50 of 1.09
mg/l after 48 hours of exposure and based on geometric mean measured
other studies with a reliability 2 according
to Klimisch are available (Devillers
et al., 1987; Rhône-Poulenc, 1977). They were well described and
followed the French
standardised method NF T90301. The 24-hour
EC50 values were 1.67 mg/L and 2.1 mg/L, respectively, which means that
the results were in agreement with the study of Seeland-Fremer et al.
Long-term toxicity to aquatic
The only chronic data available on
invertebrates was performed on a non standardized species using a non
standardized method. It is thus not possible to conclude on the
long-term toxicity of catechol to aquatic invertebrates.
Toxicity to algae
one study (Majnusz, 1994) was
reliable, with a score of 2 according to Klimisch. It was selected as a
key study, because it was well described and conducted similarly to the
OECD guideline 201. In this study, the
toxicity of the test item catechol was evaluated in the algal strain Chlorella
vulgaris during 96 hours.The
main criterion measured was the EC50, a statistically derived
concentration resulting in 50% reduction of the average specific growth
rate. The 96-hour
EC50 was 22 mg/L. There
is no indication allowing to know whether the validity criteria were
fulfilled. Based on these results, catechol is considered as
harmful to algae.
studies were not well described, or not conducted according to
recognized guidelines and were all scored as reliability 3.
Toxicity to micro-organisms
data were available on isolated species. Two of these studies were
scored as reliability 2 according to Klimisch and selected
as key studies. Based on growth inhibition of Tetrahymena pyriformis,
48h-EC50 values of 57.14 mg/L (Schultz,
1996) and 19.58
reported. In view of the chemical safety assessment, the lowest value
only reliable data available on mixed inoculum concerned anaerobic
sludge, and was of reliability 2. A 3d-EC50 = 1814 mg/L, based on
methane production inhibition, was reported in this study
other available data contain few details. They were performed using
species which are either not among those recommended by the guidelines,
or considered of a low relevance when assessing the risk for
micro-organisms from STP. Furthermore, some of the methods applied are
not enough standardised to conclude on the toxicity of catechol to
on these results, catechol could be harmful to some of the tested
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