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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No test substance information, no guideline, secondary literature, but reference handbook.

Data source

Reference
Reference Type:
review article or handbook
Title:
No information
Author:
Lewis RJ
Year:
1996
Bibliographic source:
Sax's Dangerous properties of Industrial Materials. Ninth Edition. Vol. ?. Edited and published by: Van Nostrand Reinhold. New York, NY.

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyrocatechol
EC Number:
204-427-5
EC Name:
Pyrocatechol
Cas Number:
120-80-9
Molecular formula:
C6H6O2
IUPAC Name:
pyrocatechol
Details on test material:
no data

Test animals

Species:
other: several species
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
247 mg/kg bw
Remarks on result:
other: mouse, subcutaneous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
175 mg/kg bw
Remarks on result:
other: mouse, i.p.
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
110 mL/kg bw
Remarks on result:
other: rat, subcutaneous
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
150 - 200 mg/kg bw
Remarks on result:
other: guinea pig, subcutaneous
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
160
Remarks on result:
other: frog, subcutaneous
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
40 mg/kg bw
Remarks on result:
other: dog, subcutaneous

Applicant's summary and conclusion