Registration Dossier
Registration Dossier
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EC number: 204-427-5 | CAS number: 120-80-9
Biological effects monitoring
Administrative data
- Endpoint:
- biological effects monitoring
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No particular guideline is needed, and the test is relatively well described.
Data source
Reference
- Reference Type:
- publication
- Title:
- Cytotoxicity of phenolic compounds on Dicentrarchus labrax erythrocytes.
- Author:
- Bogé G., Roche H.
- Year:
- 1 996
- Bibliographic source:
- Bull. Environ. Contam. Toxicol., 57, 171-178.
Materials and methods
- Principles of method if other than guideline:
- In vitro effects.
- GLP compliance:
- not specified
- Type of study / information:
- In vitro effects using fish erythrocytes
Test material
- Reference substance name:
- Pyrocatechol
- EC Number:
- 204-427-5
- EC Name:
- Pyrocatechol
- Cas Number:
- 120-80-9
- Molecular formula:
- C6H6O2
- IUPAC Name:
- pyrocatechol
- Details on test material:
- Purchased from Riedel-de-Haën (Seelze, Germany).
Constituent 1
Results and discussion
Any other information on results incl. tables
- Hemolysis appeared from 10 µM catechol after 24-hr
incubation. At 100 µM, 10% of the red blood cells were
hemolysed. At 1 mM, the hemolysis rate was 70%.
The decrease of ATP content was 90% at 100 µM and ca. 100% at 1 mM.
- At 100 µM, pyrocatechol significantly increased the
activities of MnSOD, peroxidase and glutathione peroxidase.
This stimulation persisted at 10 µM for MnSOD activity.
Catalase activity decreased.
According to the authors, catechol interacts with the production of oxygen radicals. This hypothesis is supported by the fact that during autoxidation of catechol, such free radicals are formed.
Applicant's summary and conclusion
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