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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data comes from a peer-reviewed handbook cited among "reference books containing peer-reviewed physico-chemical data" in the ECHA guidance document on information requirements and chemical safety assessment (R.7a).
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Medium:
other: ethyl alcohol
Solubility:
740 g/L
Temp.:
60 °C
Medium:
other: ethyl ether
Solubility:
653 g/L
Temp.:
60 °C
Medium:
acetone
Solubility:
752 g/L
Temp.:
60 °C
Medium:
benzene
Solubility:
73 g/L
Temp.:
60 °C
Medium:
other: chloroform
Solubility:
7 g/L
Temp.:
60 °C
Medium:
other: carbon tetrachloride
Solubility:
8 g/L
Temp.:
60 °C
Conclusions:
Catechol is soluble to very soluble in the organic solvents cited in this handbook.
Executive summary:

This peer-reviewed handbook reported solubility values at 60°C in different organic solvents (ethyl alcohol, ethyl ether, acetone, benzene, chloroform, carbon tetrachloride). Depending on the solvents, the values ranged from 7 to 752 g/L; indicating that catechol is soluble to very soluble in these organic solvents.

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The values of solubility in organic solvents is juste cited, without further information.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Medium:
acetone
Solubility:
660 g/L
Temp.:
20 °C
Medium:
benzene
Solubility:
8 g/L
Temp.:
20 °C
Medium:
other: ethyl alcohol
Solubility:
582 g/L
Temp.:
20
Conclusions:
Catechol is soluble to very soluble in the organic solvents cited in this publication.
Executive summary:

This publication reported solubility values at 20°C in different organic solvents (ethyl alcohol, acetone, benzene). Depending on the solvents, the values ranged from 8 to 660 g/L; indicating that catechol is soluble to very soluble in these organic solvents.

Description of key information

Solubility at 20°C: 660 g/L in acetone; 582 g/L in ethanol; 19 g/L in chloroform; 1 g/L in carbon tetrachloride; 8 g/L in benzene.
Solubility at 25°C: 740 g/L in ethyl alcohol; 653 g/L in ethyl ether; 752 g/L in acetone; 73 g/L in benzene; 7 g/L in chloroform.
Catechol is soluble to very soluble in these organic solvents.

Key value for chemical safety assessment

Additional information

A reference peer-reviewed handbook and publications give consistent values of solubility in organic solvents. Therefore, a Weight of Evidence approach was applied.