Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data comes from a peer-reviewed handbook cited among "reference books containing peer-reviewed physico-chemical data" in the ECHA guidance document on information requirements and chemical safety assessment (R.7a).
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Water solubility:
804 g/L
Temp.:
60 °C
Remarks on result:
other: No information on pH are available.
Conclusions:
Very soluble (> 10000 mg/L)
Catechol presents a water solubility value equal to 804 g/L at 60°C.
Executive summary:

A peer-reviewed handbook reports a water solubility value of 804 g/L at 60°C for catechol; indicating it is very soluble into water.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Data comes from a peer-reviewed handbook cited among "reference books containing peer-reviewed physico-chemical data" in the ECHA guidance document on information requirements and chemical safety assessment (R.7a). A publication, cited in the same endpoint study record, gives an identical value as the handbook.
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Water solubility:
451 g/L
Temp.:
20 °C
Remarks on result:
other: No information on pH are available.
Conclusions:
Very soluble (> 10000 mg/L)
Catechol present a water solubility value equal to 451 g/L at 20°C.
Executive summary:

A peer-reviewed handbook and a IUPAC publication report a similar water solubility value of 451 g/L at 20°C for catechol; indicating it is very soluble into water.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The value is just cited in the publication, without furhter information. The reported result is consistent with those of the peer-reviewed handbooks.
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Water solubility:
584 g/L
Temp.:
20 °C
Remarks on result:
other: No information on pH are available.
Conclusions:
Very soluble (> 10000 mg/L)
Catechol presents a water solubility value equal to 584 g/L at 20°C.
Endpoint:
water solubility
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The publication described a calculation method giving a result in accordance with experimental data, but no sufficient details are provided.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Calculation method
GLP compliance:
no
Type of method:
other: calculated
Water solubility:
235 g/L
Temp.:
25 °C
Remarks on result:
other: No information on pH are available.
Details on results:
log Swater =0.33
Conclusions:
Very soluble (> 10000 mg/L)
Catechol presents a calculated water solubility value of 235 g/L at 25°C.

Description of key information

Water solubility range: 235 to 584 g/L at 20 - 25°C.
Catechol is thus very soluble in water.

Key value for chemical safety assessment

Water solubility:
517.5 g/L
at the temperature of:
20 °C

Additional information

Reference peer-reviewed handbooks and publications give consistent values, reflecting a high water solubility of catechol. A "weight of evidence" approach was thus applied. An average of all the data at 20 °C was calculated to obtain the key value for chemical safety assessment.