Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-427-5
CAS number: 120-80-9
studies were available, one for reprotoxicity and two for teratogenicity. Only
one study was considered as validity 2, it is a combined repeated dose
toxicity study with the Reproduction/Developmental Toxicity Screening
Test (OECD 422).
study of R. Ceccatelli (2009), catechol was administered by gavage at
doses of 0, 30, 80, 160 mg/kg body weight/day to male rats for at least
28 days and to female rats for 14 days prior to pairing, through the
pairing and gestation periods until the F1 generation reached day 4 post
partum. For general toxicity the main effect reported was at 80 and 160
mg/kg/day, incidence and severity of squamous hyperplasia in the stomach
for both sexes. This lesion represents a localized stomach reaction to a
repeatedly gavages irritant test material.
and Breeding regarding mean
precoital time, conception rate, fertility and gestation indexes were
not affected by the treatment with the test item. Same conclusion for
implantation rate and post-implantation loss. The treatment with the
test item did not reveal any effects on the completeness of stages or
cell populations of the testes.
number of pups at first litter check and on day 4 post partum was not
affected by the treatment with the test item. The sex ratio was also not
development was not affected by the treatment with the test item. At
necropsy of pups, no test item-related findings were noted.
NOEL (No Observed Effect Level) was considered to be 30 mg/kg/day, due
to the squamous hyperplasia in the stomach. This lesion represents a
localized stomach reaction to a repeatedly gavage irritant test material.
The NOEL for
reproduction/developmental toxicity was considered to be 160 mg/kg/day,
the highest dose tested without observed effect.
carcinogenicity studies, the reproductive organs were observed and no
effects were reported indicating that catechol did not affect the
no valid data are available
teratogenicity studies were considered of low validity (Klimisch 3) so possible
teratogenic effect of Catechol could not be evaluated.
Regarding results available in the
OECD study 422 and according to classification criteria of EC
regulation 1272/2008 the catechol should not be classified for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again