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EC number: 204-427-5 | CAS number: 120-80-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The LD50 was calculated but the calcul method used is not explained.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pyrocatechol
- EC Number:
- 204-427-5
- EC Name:
- Pyrocatechol
- Cas Number:
- 120-80-9
- Molecular formula:
- C6H6O2
- IUPAC Name:
- pyrocatechol
- Details on test material:
- Rhône-Poulenc, Catechol lot 30488 R.P.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- other: distilled water
- Duration of exposure:
- 24 hours
- Doses:
- 125, 875, 1125 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - 2,5 ml/kg of the substance solution was placed and carefully spread out over a beforehand shaven cutaneous zone of the area of the back (surface of approximately 4 X 7 cm; which corresponds to a little less than 10% of total body surface).
- animals were placed after treatment in individual cages and they are fitted with a collar to prevent that they do not lick.
- 24 hours after treatment, the surviving animals were released from their collar and the zone of application was carefully washed with warm soapy water, then dried.
- Animals were observed during 15 days after treatment.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Mortality:
- 0/10 at 125 mg/kg.
10/10 at 875 and 1125 mg/kg. - Clinical signs:
- other: other: At 125 mg/kg: none. At 875 and 1125 mg/kg, rats presented tremors 5 minutes after dermal application, and died within 30 minutes after clonic convulsions.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
Catechol is classified as "toxic in contact with skin" in the GHS system (EU). The classification required under EU GHS Regulation is Acute. Tox. cat. 3, H311.- Executive summary:
In an acute dermal toxicity study (Rhône-Poulenc, 1973), CD male and female rats (5/sex/group) were dermally exposed to catechol for a maximum of 24 hours to their back, at doses of 125, 875 and 1125 mg/kg bw. Animals then were observed for 15 days.
Dermal LD50Combined= 600 mg/kg bw.
Catechol is toxic in contact with skin based on the LD50 in rats and according to EU GHS Regulation.
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