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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The LD50 was calculated but the calcul method used is not explained.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyrocatechol
EC Number:
204-427-5
EC Name:
Pyrocatechol
Cas Number:
120-80-9
Molecular formula:
C6H6O2
IUPAC Name:
pyrocatechol
Details on test material:
Rhône-Poulenc, Catechol lot 30488 R.P.

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
open
Vehicle:
other: distilled water
Duration of exposure:
24 hours
Doses:
125, 875, 1125 mg/kg b.w.
No. of animals per sex per dose:
5
Control animals:
not required
Details on study design:
- 2,5 ml/kg of the substance solution was placed and carefully spread out over a beforehand shaven cutaneous zone of the area of the back (surface  of approximately 4 X 7 cm; which corresponds to a little less than 10% of total body surface).
- animals were placed after treatment in individual cages and they are fitted with a collar to prevent that they do not lick.
- 24 hours after treatment, the surviving animals were released from their collar and the zone of application was carefully washed with warm soapy water, then dried.
- Animals were observed during 15 days after treatment.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
600 mg/kg bw
Mortality:
0/10 at 125 mg/kg.
10/10 at 875 and 1125 mg/kg.
Clinical signs:
At 125 mg/kg: none.
At 875 and 1125 mg/kg, rats presented tremors 5 minutes after dermal application, and died within 30 minutes after clonic convulsions.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:

Catechol is classified as "toxic in contact with skin" in the GHS system (EU). The classification required under EU GHS Regulation is Acute. Tox. cat. 3, H311.
Executive summary:

In an acute dermal toxicity study (Rhône-Poulenc, 1973), CD male and female rats (5/sex/group) were dermally exposed to catechol for a maximum of 24 hours to their back, at doses of 125, 875 and 1125 mg/kg bw. Animals then were observed for 15 days.

 

Dermal LD50Combined=  600 mg/kg bw.

 

Catechol is toxic in contact with skin based on the LD50 in rats and according to EU GHS Regulation.

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