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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The purity of the test substance and the strain of rat used are not known. The administration volume and the use of vehicle are not specified.

Data source

Reference
Reference Type:
publication
Title:
The benzenediols: catechol, resorcinol and hydroquinone: a review of the industrial toxicology and current industrial exposure limits.
Author:
Flickinger C.W.
Year:
1976
Bibliographic source:
American Industrial Hygiene Association Journal, 37(10), 596-606.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Federal register (see below)
Deviations:
not specified
Principles of method if other than guideline:
Federal Register (1961) pp. 7333-7341, Part 191- Hazardous Substances: Definitions and Procedural and Interpretative Regulations, Final Order
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyrocatechol
EC Number:
204-427-5
EC Name:
Pyrocatechol
Cas Number:
120-80-9
Molecular formula:
C6H6O2
IUPAC Name:
pyrocatechol
Details on test material:
Koppers Company, Inc, Catechol C.P. Crystal Lot 68-1.

Test animals

Species:
rat
Strain:
other: albino
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
158, 316, 630 and 1260 mg/kg bw
No. of animals per sex per dose:
5 males per dose
Control animals:
yes
Details on study design:
- Rats were observed during a 14-day post-exposure period.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
300 mg/kg bw
95% CL:
200 - 500
Mortality:
0/5 rat died at the dose of 158 mg/kg bw.
2/5 rats died at the dose of 316 mg/kg bw on day 1 and 2.
5/5 rats died at the dose of 630 mg/kg bw by day 1.
5/5 rats died at the dose of 1260 mg/kg bw within 1 hour.
Clinical signs:
no data
Body weight:
Except one of the surviving rats, all showed body weight gains increase within significant limits of those of control animals.
Gross pathology:
None of the rats sacrificed following the holding period exhibited any gross lesions upon pathological examination.
Other findings:
The rats that died during the observation period revealed hyperaemia of the stomach and intestine.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:

Based on this study, Catechol is classified as Acute. Tox. Category 3, H301 according to EU GHS Regulation.
Executive summary:

In an acute oral toxicity study (Flickinger, 1967), groups of 5 albino male rats were given a single oral dose of catechol at doses of 0, 158, 316, 630 and 1260 mg/kg bw and observed for 14 days.

No death occured at 158 mg/kg bw, 2/5 died at 316 mg/kg bw and 5/5 at 630 mg/kg bw.

No clinical signs were reported and the autopsy revealed for rats died during the study: hyperemia of the stomach and intestines. None of the rats sacrifed at the end of the experiment revealed gross pathology during pathological examination.

 

Oral LD50Males = 300 mg/kg bw (95% C.L. 200-500 mg/kg)

Catechol is considered to be toxic if swallowed based on the LD50 obtained.