Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-427-5 | CAS number: 120-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Notice of intended changes - Catechol, kaolin, and arsenic.
- Author:
- Anonymous
- Year:
- 1 991
- Bibliographic source:
- Appl. Occup. Environ. Hyg., 6(12), 1042-1043.
- Reference Type:
- publication
- Title:
- No information
- Author:
- Hirosawa I., Asaeda G., Arizono H., Shimbo S.-I., Ikeda M.
- Year:
- 1 976
- Bibliographic source:
- International Archives of Occupational Environmental Health, 37(2),107-114.
Materials and methods
- Study type:
- health record from industry
Test material
- Reference substance name:
- Pyrocatechol
- EC Number:
- 204-427-5
- EC Name:
- Pyrocatechol
- Cas Number:
- 120-80-9
- Molecular formula:
- C6H6O2
- IUPAC Name:
- pyrocatechol
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- Japanese study on 13 workers exposed during 2 years to catechol (2 to 72 ppm) and phenol (55 to 260 ppm) vapours:
* The workers studied aged from 23 to 56 years and were engaged in shift work (7-9 h per day) for 2 years in a chemical factory where phenols were produced.
* Urine samples were collected to cover 24 starting at the begining of the shift. Twenty four-h samples were also collected when the workers were away from the exposure for a month. for the analysis of catecholamines and their metabolites, the urine was mixed with one-hundred volume of 35% hydrochloric acid and kept frozen for less than two weeks until analysed.
* Phenol and catechol were measured in Air and in Urine samples.
Catecholamines and related metabolites were measured in Urine samples.
Haemograms, other clinical examination, subjective symptoms (using the Cornell Medical Index Health Questionnaire) were evaluated. And Statistical analyses were performed using t test.
* Sex and aged-matched controls, 13 subjects, were selected from clerks in the business section of the same factory.
Results and discussion
- Results:
- * The workers were usually in the monitoring room with occasional walk to and from various instruments including a centrifuge and a flaking machine. Exposure intensity, thererfore, was such that the workers were exposed to around 8 ng/m3 of catechol and 214 ng/m3 of phenol for 8 hours in general with occasional exposure up to 320 ng/m3 of catechol and 1000 ng/m3 of phenol. The most intensive exposure was in the packing room, where the exposure period was about 4h a day on the average.
* Physical response of workers:
- Many were complaining of sore throats, cough and sputa and eyes irritation, confirmed by clinical examination.
- Compared with the frequency of symptoms in control subjects, significant increases (p < 0.05) in positive response related to upper respiratory disorder were given (9 of 12).
- Higher incidence of cutaneous disorders than in control population.
- Although catechol is a well-known inhibitor of catecholamine o-methyl transferase, the exposure at the level studied did not modify catecholamine metabolism, the daily excretion of catecholamines and their metabolites in urine remained within the normal range except for a slight decrease in perature during and right after the exposure also remained normal.
There no signs of hepatic and renal dysfunction. Peripheral haemograms were normal in all examinees except for one case of slight anaemia observed in a 56 year-old male worker.
* Excretion data are presented in Chapter 5.0. The calculated half-life of inhaled catechol is between 3 and 7 hours.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.