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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline study; not GLP
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-mercaptopropionic acid
EC Number:
203-537-0
EC Name:
3-mercaptopropionic acid
Cas Number:
107-96-0
Molecular formula:
C3H6O2S
IUPAC Name:
3-sulfanylpropanoic acid
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
undiluted
Amount applied: 0.1 g
Duration of treatment / exposure:
30 sec / unlimited
Observation period (in vivo):
14 d
Number of animals or in vitro replicates:
1
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): one eye was rinsed after 30 sec, the other treated eye was not rinsed
- Time after start of exposure: 30 sec


SCORING SYSTEM: no data


TOOL USED TO ASSESS SCORE: fuorescein

Results and discussion

In vivo

Irritant / corrosive response data:
Instillation of 3-mercaptopropionic acid into a rabbit's eyes resulted in severe pain, severe corneal injury and severe conjunctival inflammation.  These effects were noted immediately after instillation and persisted through 14 days of observation.  The response of the washed eye was the same as that in the eye which was not washed.  This indicates the damage to the cornea was permanent.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
MPA is corrosive and causes serious eye damage.