3-mercaptopropionic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008.01.05-2008.04.24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

other substance amounts and equilibration times used

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss Federal Office of Public Health, Consumer protection directorate, Notification Authority for Chemicals, 3003 Bern, Switzerland

Type of method:

other: simplified flask method

Water solubility:

> 603.7 g/L

Temp.:

20 °C

pH:

ca. 1.8

Details on results:

Two measurements of water solubility of 3-Mercaptopropionic Acid at room temperature were performed and values 618,9 and 588.4 g/L were recorded. Water solubility was found to be more than 603.7 g/L (mean value from two measurements according to HPLC measurements within the study). Because it was not possible to prepare a saturated solution, the water solubility might be higher than determined in the present study. The water solubility was not corrected for the purity of the test item.

Executive summary:

Water solubility has been determined to be more than 603.7 g/L by using the simplified flask method. The study followed the procedures indicated by OECD Guideline No. 105 "Water solubility" and EEC Directive 92/69 (Method A.6 "Water solubility"). Based on the high solubility found in the preliminary test a main test as described in the guideline was not performed.

 

Description of key information

Water solubility: >=603.7 g/L at room temperature

Key value for chemical safety assessment

Water solubility:

604 g/L

at the temperature of:

20 °C

Additional information

Study performed in experimental laboratory (Franke, 2008, RCC) dedicated to estimate water solubility of the test material 3-Mercaptopropionic Acid has been chosen as a key study. Water solubility has been determined to be more than 603.7 g/L by using the simplified flask method. The study followed the procedures indicated by OECD Guideline No. 105 "Water solubility" and EEC Directive 92/69 (Method A.6 "Water solubility"). Based on the high solubility found in the preliminary test a main test as described in the guideline was not performed.

Another study (Rampy, 1973, Dow) qualitatively supports the result obtained in the key study and reports complete solubility of test substance in water.