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EC number: 203-537-0 | CAS number: 107-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18-19 July 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study; GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-mercaptopropionic acid
- EC Number:
- 203-537-0
- EC Name:
- 3-mercaptopropionic acid
- Cas Number:
- 107-96-0
- Molecular formula:
- C3H6O2S
- IUPAC Name:
- 3-sulfanylpropanoic acid
- Details on test material:
- - Name of test material (as cited in study report): 3-mercaptopropionic acid
- Physical state: clear colourless liquid
- Analytical purity: 99.8% (GC)
- Purity test date: 2002-03-27
- Lot/batch No.: 1672
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- other: human in vitro
- Details on test animals or test system and environmental conditions:
- EpiDerm Skin Model (MatTek, Ashland, MA, USA)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 50 µL, undiluted
- Duration of treatment / exposure:
- 3 min, 60 min
- Observation period:
- 3 h
- Number of animals:
- duplicate tissues were used per exposure time
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): At the end of the exposure period each EpiDerm tissue was rinsed using Dulbecco’s phosphate buffered saline (DPBS).
- Time after start of exposure: 3 min, 60 min
SCORING SYSTEM: Data are presented in the form of % viability (MTT conversion relative to negative controls) for each of the two exposure times.
Classification of corrosivity potential was based on relative viabilities for both exposure times according to the Table 1 (Material & Methods).
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- after 60 min exposure
- Value:
- 5.24
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- after 3 min exposure
- Value:
- 5.26
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- see table 2 under "Any other information on results"
Any other information on results incl. tables
The relative mean viability was 5.26% after 3 minutes exposure, and 5.24% after 60 minutes exposure. The relative mean viability of the test material-treated tissues was <10% after 3 minutes exposure.
Table 2: Mean OD540Values and Mean % Viabilities for the Negative Control, Positive Control Material and Test Material
Material |
Exposure Time |
Mean OD5401 |
Mean % Viability1 |
Negative control |
3 minute |
1.977 |
100% |
60 minute |
1.986 |
100% |
|
Positive Control |
3 minute |
0.109 |
5.512 |
60 minute |
0.100 |
5.043 |
|
Test Material |
3 minute |
0.104 |
5.262 |
60 minute |
0.104 |
5.243 |
1= Mean of 2 EpiDerm tissues tested in duplicate
2= Mean viability expressed as a percentage of the mean viability of the 3 minute negative control tissues
3= Mean viability expressed as a percentage of the mean viability of the 60 minute negative control tissues
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information C, R35 Criteria used for interpretation of results: EU
- Conclusions:
- The test material is considered to have the potential to be corrosive in-vivo.
The symbol “C” and the highest risk phrase R35 “Causes severe burns” are required.
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