3-mercaptopropionic acid

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: non-GLP study, but sufficient for C&L.

Cross-reference

Reason / purpose:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report Date:

1973

Materials and methods

Principles of method if other than guideline:

Method: other

GLP compliance:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals and environmental conditions:

not reported

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

no data

Duration of treatment / exposure:

7 hour(s)

Number of animals:

1

Results and discussion

Any other information on results incl. tables

Necrosis and burns were observed within 15 minutes of application of test material.  These were accompanied by erythema and edema.

Applicant's summary and conclusion

Interpretation of results:

Category 1B (corrosive) based on GHS criteria

Remarks:

Migrated information

Conclusions:

3-MPA is highly corrosive in vivo.