Registration Dossier

Diss Factsheets

Administrative data

Description of key information

MPA is toxic if swallowed and harmful by inhalation. Percutaneous toxicity cannot be determined because of the corrosivity of MPA.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
120 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
1 818 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

MPA is highly corrosive. Inhalation exposure caused irritation of the respiratory tract which finally led to mortality.

Justification for classification or non-classification

LD50(oral) = 120 mg/kg bw

LC50(4 -h inhal, mist) = 1.8 mg/L

EU classification: T, R25-20 -37. Toxic if swallowed. Harmful by inhalation. Irritating to respiratory system.

GHS classification: Acute Oral Cat. 3, Acute Inhal Cat.4., STOT SE3; H301: Toxic if swallowed. H332: Harmful if inhaled. H335: May cause

respiratory irritation.