Registration Dossier
Registration Dossier
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EC number: 203-537-0 | CAS number: 107-96-0
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: publication using subcutaneous injection (irrelevant route of exposure)
Data source
Reference
- Reference Type:
- publication
- Title:
- 3-MERCAPTOPROPIONIC ACID: CONVULSANT PROPERTIES, EFFECTS ON ENZYMES OF THE 7-AMINOBUTYRATE SYSTEM IN MOUSE BRAIN AND ANTAGONISM BY CERTAIN ANTICONVULSANT DRUGS, AMINOOXYACETIC ACID AND GABACULINE.
- Author:
- Löscher, W.
- Year:
- 1 979
- Bibliographic source:
- Biochemical Pharmacology, Vol. 28, pp. 1397-1407.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-mercaptopropionic acid
- EC Number:
- 203-537-0
- EC Name:
- 3-mercaptopropionic acid
- Cas Number:
- 107-96-0
- Molecular formula:
- C3H6O2S
- IUPAC Name:
- 3-sulfanylpropanoic acid
- Details on test material:
- purchased from Merck (Darmstadt, Germany)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
TEST ANIMALS
- Source: Bomholtgard, Ry, Denmark
- Weight at study initiation: 24-30 g
- Fasting period before study:
- Housing: groups of 10 in Makrolon vages
- Diet (ad libitum): Altromin
- Water (e.g. ad libitum): no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24-26°C
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
60 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Subcutaneous injection of 3-mercaptopropionic acid (MP) into mice caused severe convulsions which started after about 6 min and were paralleled by a large, reversible inhibition of glutamate decarboxylase (GAD) and activation of (GABA)-a-oxoglutarate aminotransferase (GABA-T) in the brain. The central (GABA) level, determined by a newly developed gas chromatographic method, was not altered after administration of the CD 97 of MP (60 mg/kg) but decreased after doubling or tripling the dose. The results suggest a role played by the GABA system in the convulsant action of MP and in the antiseizure activity of several clinically useful anticonvulsants as well as AOAA and gabaculine. With respect to the GABA system, MP seems to be a useful tool in studies of experimental epilepsy.
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