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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data to determine reliability

Data source

Reference
Reference Type:
review article or handbook
Title:
Unpublished data Eastman Kodak.
Author:
Fassett, D.W.
Year:
1963
Bibliographic source:
Summarized in Patty's Industrial Hygiene and Toxicology |2nd Ed. Interscience Publishers, New York, New York.

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Vehicle:
water

Results and discussion

Any other information on results incl. tables

RS-Freetext:
Neat material appears to be absorbed directly through the
guinea pig skin with deaths from as low as 5 ml/kg.  Severe
delayed eschar formation was noted.

A 10% solution in water applied as a compress to guinea pig
skin produces severe damage and eschar.  No deaths were
produced at this concentration.

No additional information provided.

Applicant's summary and conclusion