Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
88.3 mg/kg bw/day
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information

The reproductive NOAEL for the methyl ester of 3-mercaptopropionic acid (MMP) is 100 mg/kg/d. The MW of 3-mercaptopropionic acid (3-MPA) corresponds to 88.3% of the MW of MMP. The NOAEL is accordingly corrected to 88.3 mg/kg/d.


Short description of key information:
No effects on fertility were noted in a screening study conducted according to OECD TG 422 with the methyl ester of 3-mercaptopropionic acid.

Effects on developmental toxicity

Description of key information
No effects on pre-natal development were noted in a screening study conducted according to OECD TG 422 with the methyl ester of 3-mercaptopropionic acid.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
88.3 mg/kg bw/day
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information

The developmental NOAEL of the methyl ester of 3-mercaptopropionic acid (MMP) is 100 mg/kg/d. The MW of 3-mercaptopropionic acid (3-MPA) corresponds to 88.3% of the MW of MMP. The NOAEL is accordingly corrected to 88.3 mg/kg/d.

Justification for classification or non-classification