Registration Dossier

Administrative data

Description of key information

3-MPA has shown skin corrosivity in vitro and in vivo. It caused irreversible cornea damage in one rabbit. Rats exposed to 3-MPA aerosol exhibited irritation of the respiratory tract only at high dosages.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on skin irritation/corrosion: highly corrosive

Effects on eye irritation: highly corrosive

Effects on respiratory irritation: irritating

Justification for classification or non-classification

3-MPA has to be classified as strongly corrosive, based on in vivo and in vitro results.

EU classification: C, R35. Causes severe burns.

GHS classification: Danger, Skin Corrosive. Category 1B; H314: Causes severe skin burns and eye damage.