Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 248-666-3 | CAS number: 27813-02-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Remarks:
- Review of publicly available data for the structured identification of respiratory sensitizers
- Type of information:
- other: Literature review
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Identifying a reference list of respiratory sensitizers for the evaluation of novel approaches to study respiratory sensitization
- Author:
- Sadekar N. et al.
- Year:
- 2 022
- Bibliographic source:
- Critical Reviews in Toxicology, 51:10, 792-804, DOI: 10.1080/10408444.2021.2024142
Materials and methods
- Type of study / information:
- Literature review
- Endpoint addressed:
- respiratory sensitisation
- Principles of method if other than guideline:
- This review aims to sort suspected LMW respiratory sensitizers based on available compelling, reasonable, inadequate, or questionable evidence in humans from occupational exposures and use this information to compose a reference list of reported chemical respiratory sensitizers for scientific
research purposes. - GLP compliance:
- no
Test material
Method
- Ethical approval:
- not applicable
Results and discussion
- Results:
- HPMA was assessed with "inadequate evidence" being a respiratory sensitiser.
Any other information on results incl. tables
Identified literature for HPMA was Lindstrom et al. (2002); Hagberg et al. (2005)
Applicant's summary and conclusion
- Executive summary:
On basis of a scientifically valid literature search followed by a structured data assessment, the evidence for HPMA was considered by the authors as "inadequate", the third quality level of four (compelling >reasonable > inadequate > questionable evidence).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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