Registration Dossier
Registration Dossier
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EC number: 248-666-3 | CAS number: 27813-02-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: QSPR
- Remarks:
- Based on an established human skin model by Potts and Guy (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Generally accepted calculation method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
- GLP compliance:
- no
Test material
- Reference substance name:
- Methacrylic acid, monoester with propane-1,2-diol
- EC Number:
- 248-666-3
- EC Name:
- Methacrylic acid, monoester with propane-1,2-diol
- Cas Number:
- 27813-02-1
- Molecular formula:
- C7H12O3
- IUPAC Name:
- 1-hydroxypropan-2-yl 2-methylprop-2-enoate; 2-hydroxypropyl 2-methylprop-2-enoate
- Reference substance name:
- Methacrylic acid monoester with 1,2-propandiol
- IUPAC Name:
- Methacrylic acid monoester with 1,2-propandiol
- Details on test material:
- TS-Freetext:
Purity: 98 %
Constituent 1
Constituent 2
Test animals
- Species:
- other: human skin model
- Details on test animals or test system and environmental conditions:
- not applicable; in silico modelling
Administration / exposure
- Type of coverage:
- other: not applicable; in silico modelling
- No. of animals per group:
- not applicable; in silico modelling
Results and discussion
- Absorption in different matrices:
- predicted flux 150.8 μg/cm²/h; the relative dermal absorption is high
Any other information on results incl. tables
Based on a molecular weight of 144.17 g/mol and a g Kow of 0.97, the predicted flux of HPMA is 150.8 μg/cm²/h; the relative dermal absorption is high.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of HPMA is predicted to be high; the predicted flux is 150.8 μg/cm²/h.
- Executive summary:
The dermal absorption (steady-state flux) of HPMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.
Based on a molecular weight of 144.17 g/mol and a logKow of 0.97, the predicted flux of HEMA is 150.8μg/cm²/h; the relative dermal absorption is high.
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