Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-666-3 | CAS number: 27813-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity studies with methacrylic acid, monoester with propane-1,2-diol were conducted in fish, invertebrates, and algae.
For fish, one acute study with the golden orfe (Leuciscus idus melanotus) was available for assessment. The LC50 was >493 mg/L and based on an acute 48-hour static exposure. Though the exposure was conducted for 48 hours instead of the standard 96-hour exposure, the results from this study was sufficient to assess the toxicity of the substance to fish and determine that fish are not the most sensitive trophic level. Long-term testing in fish is waived for methacrylic acid, monoester with propane-1,2-diol since the substance is classified as readily biodegradable and has a low potential for bioaccumulation (log Pow = 0.97). In addition, the risk characterization shows that the PEC/PNECaqua ratio for the aquatic environment is <1, indicating no need for further information or testing.
For invertebrates, one acute and one chronic study with Daphnia magna were available for assessment. The EC50 was >143 mg/L, based on the acute 48-hour semi-static limit test exposure. Based on the chronic 21-day semi-static exposure, the NOEC for reproduction was 45.2 mg/L.
For the algal species, one study with Pseudokirchnerella subcapitata as the test species was available for assessment. The EC50 and NOEC for the freshwater species were both >97.2 mg/L, the highest concentration tested and based on growth rate following 72-hours of exposure.
An investigation with a similar substance (methacrylic acid) and 12 marine species (fish, invertebrates, several algae) gave no indication of a higher sensitivity of marine species compared to freshwater species. To the contrary, LC/EC50 values and NOECs tended to be higher than the corresponding freshwater data (Sverdrup, et al., 2001).
Toxicity to microorganisms testing is waived for methacrylic acid, monoester with propane-1,2-diol since it is classified as readily biodegradable at an application concentration (100 mg/L), which is greater than the predicted environmental concentration (PEC) in the influent of the sewage treatment plant (STP).
Taken together, the lowest aquatic toxicity value for methacrylic acid, monoester with propane-1,2 -diol was the NOEC of 45.2 mg/L, based on the 21 -day chronic toxicity test with Daphnia magna.
References:
Sverdrup LE, Kaellqvist T, Kelley AE, Fuerst CS, Hagen SB (2001).Comparative toxicity of acrylic acid to marine and freshwater microalgae and the significance for environmental effects assessments. Chemosphere 45(4-5) 653 - 658.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.