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EC number: 248-666-3 | CAS number: 27813-02-1
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity studies with methacrylic acid, monoester with propane-1,2-diol were conducted in fish, invertebrates, and algae.
For fish, one acute study with the golden orfe (Leuciscus idus melanotus) was available for assessment. The LC50 was >493 mg/L and based on an acute 48-hour static exposure. Though the exposure was conducted for 48 hours instead of the standard 96-hour exposure, the results from this study was sufficient to assess the toxicity of the substance to fish and determine that fish are not the most sensitive trophic level. Long-term testing in fish is waived for methacrylic acid, monoester with propane-1,2-diol since the substance is classified as readily biodegradable and has a low potential for bioaccumulation (log Pow = 0.97). In addition, the risk characterization shows that the PEC/PNECaqua ratio for the aquatic environment is <1, indicating no need for further information or testing.
For invertebrates, one acute and one chronic study with Daphnia magna were available for assessment. The EC50 was >143 mg/L, based on the acute 48-hour semi-static limit test exposure. Based on the chronic 21-day semi-static exposure, the NOEC for reproduction was 45.2 mg/L.
For the algal species, one study with Pseudokirchnerella subcapitata as the test species was available for assessment. The EC50 and NOEC for the freshwater species were both >97.2 mg/L, the highest concentration tested and based on growth rate following 72-hours of exposure.
An investigation with a similar substance (methacrylic acid) and 12 marine species (fish, invertebrates, several algae) gave no indication of a higher sensitivity of marine species compared to freshwater species. To the contrary, LC/EC50 values and NOECs tended to be higher than the corresponding freshwater data (Sverdrup, et al., 2001).
Toxicity to microorganisms testing is waived for methacrylic acid, monoester with propane-1,2-diol since it is classified as readily biodegradable at an application concentration (100 mg/L), which is greater than the predicted environmental concentration (PEC) in the influent of the sewage treatment plant (STP).
Taken together, the lowest aquatic toxicity value for methacrylic acid, monoester with propane-1,2 -diol was the NOEC of 45.2 mg/L, based on the 21 -day chronic toxicity test with Daphnia magna.
References:
Sverdrup LE, Kaellqvist T, Kelley AE, Fuerst CS, Hagen SB (2001).Comparative toxicity of acrylic acid to marine and freshwater microalgae and the significance for environmental effects assessments. Chemosphere 45(4-5) 653 - 658.
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