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Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: other route
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only summary of the studies available. No details.

Data source

Reference
Title:
No information
Author:
Rohm & Haas, personal communication (1994), unpublished|report, Rohm & Haas, No. 91R-0119 (1991)

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylic acid, monoester with propane-1,2-diol
EC Number:
248-666-3
EC Name:
Methacrylic acid, monoester with propane-1,2-diol
Cas Number:
27813-02-1
Molecular formula:
C7H12O3
IUPAC Name:
2-hydroxypropyl methacrylate

Test animals

Species:
rabbit
Strain:
New Zealand White

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
4 weeks
Frequency of treatment:
Single daily injections, 5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 6, 60 mg/kg body weight
Control animals:
yes, concurrent vehicle

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 60 other: mg/kg

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No treatment related deaths. No clinical signs. Thickening
of the skin, scrabs and scores in the 60 mg/kg/day group. No
systemic toxicity. NOAEL for systemic toxicity > 60
mg/kg/day.

Applicant's summary and conclusion

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