Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: dermal
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment. Limited no. of animals; short duration of study

Data source

Reference
Title:
No information
Author:
ICI; Hydroxyethyl methacrylate - Toxicological properties;|Imperial Chemical Industries Limited Industrial Hygiene|Research Laboratories; unpublished report, report No. TR/555|(25.10.1966)

Materials and methods

Principles of method if other than guideline:
Method: other: no data specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylic acid, monoester with propane-1,2-diol
EC Number:
248-666-3
EC Name:
Methacrylic acid, monoester with propane-1,2-diol
Cas Number:
27813-02-1
Molecular formula:
C7H12O3
IUPAC Name:
2-hydroxypropyl methacrylate
Constituent 2
Reference substance name:
Reference substance 001
Details on test material:
TS-Freetext:
Purity: 98.6 %
Inhibitor: 200 ppm Hydroquinone
The substance tested consists of a isomeric mixture ca. 20 %
2-Propenoic acid, 2-methyl, 2-hydroxy-1-methylethylester and
ca. 80 % 2-Propenoic acid, 2-methyl, 2-hydroxypropylester
(Cas: 923-26-2).

Test animals

Species:
rat
Sex:
female

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
1 week
Frequency of treatment:
6 alternate 24 hour application
Doses / concentrations
Remarks:
Doses / Concentrations:
undiluted material, occlusive
Basis:

Control animals:
other: no data specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Neither local nor systemic ill-effects.

Applicant's summary and conclusion

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