Registration Dossier
Registration Dossier
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EC number: 248-666-3 | CAS number: 27813-02-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Limited no. of animals; short duration of study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Methacrylic acid, monoester with propane-1,2-diol
- EC Number:
- 248-666-3
- EC Name:
- Methacrylic acid, monoester with propane-1,2-diol
- Cas Number:
- 27813-02-1
- Molecular formula:
- C7H12O3
- IUPAC Name:
- 1-hydroxypropan-2-yl 2-methylprop-2-enoate; 2-hydroxypropyl 2-methylprop-2-enoate
- Reference substance name:
- Methacrylic acid monoester with 1,2-propandiol
- IUPAC Name:
- Methacrylic acid monoester with 1,2-propandiol
- Details on test material:
- TS-Freetext:
Purity: 98.6 %
Inhibitor: 200 ppm Hydroquinone
The substance tested consists of a isomeric mixture ca. 20 %
2-Propenoic acid, 2-methyl, 2-hydroxy-1-methylethylester and
ca. 80 % 2-Propenoic acid, 2-methyl, 2-hydroxypropylester
(Cas: 923-26-2).
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 1 week
- Frequency of treatment:
- 6 alternate 24 hour application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
undiluted material, occlusive
Basis:
- Control animals:
- other: no data specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Neither local nor systemic ill-effects.
Applicant's summary and conclusion
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