Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation sufficient for assessment.

Data source

Reference
Title:
No information
Author:
ICI; Hydroxyethyl methacrylate - Toxicological properties;|Imperial Chemical Industries Limited Industrial Hygiene|Research Laboratories; unpublished report, report No. TR/555|(25.10.1966)

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylic acid, monoester with propane-1,2-diol
EC Number:
248-666-3
EC Name:
Methacrylic acid, monoester with propane-1,2-diol
Cas Number:
27813-02-1
Molecular formula:
C7H12O3
IUPAC Name:
1-hydroxypropan-2-yl 2-methylprop-2-enoate; 2-hydroxypropyl 2-methylprop-2-enoate
Constituent 2
Reference substance name:
Reference substance 001
Details on test material:
TS-Freetext:
Purity: 98.6 %
Inhibitor: 200 ppm Hydroquinone
The substance tested consists of a isomeric mixture ca. 20 %
2-Propenoic acid, 2-methyl, 2-hydroxy-1-methylethylester and
ca. 80 % 2-Propenoic acid, 2-methyl, 2-hydroxypropylester
(Cas: 923-26-2).

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
No. of animals per sex per dose:
18

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
500 - 1 000 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
LD50:  500 - 1000 mg/kg for male rats
LD50: 1000 - 2000 mg/kg for female rats

Applicant's summary and conclusion