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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Correlation of teratogenicity and molecular structure: ethylenethiourea and related compounds
Author:
Ruddick, J.A.
Year:
1976
Bibliographic source:
Teratology, 13:263–266.
Reference Type:
secondary source
Title:
Thiourea
Author:
Ziegler-Skylakakis, K.
Year:
2003
Bibliographic source:
Concise international chemical assessment document 49, World Health Organization, International Programme on Chemical Safety (IPCS), Geneva

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Administration of the test item to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg bw.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiourea
EC Number:
200-543-5
EC Name:
Thiourea
Cas Number:
62-56-6
Molecular formula:
CH4N2S
IUPAC Name:
thiourea
Test material form:
solid: particulate/powder

Administration / exposure

Route of administration:
not specified
Analytical verification of doses or concentrations:
not specified
Doses / concentrations
Dose / conc.:
480 mg/kg bw/day (nominal)
Remarks:
single dose

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:
Maternal toxic effects:no effects

Effect levels (maternal animals)

Dose descriptor:
NOEL
Effect level:
480 mg/kg bw/day (nominal)
Basis for effect level:
other: maternal toxicity

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:no effects

Effect levels (fetuses)

Dose descriptor:
NOEL
Effect level:
480 mg/kg bw/day (nominal)
Basis for effect level:
other: teratogenicity

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Thiourea had neither a maternally toxic nor a teratogenic effect when administered to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg body weight.
Executive summary:

Thiourea had neither a maternally toxic nor a teratogenic effect when administered to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg body weight.