Registration Dossier
Registration Dossier
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EC number: 200-543-5 | CAS number: 62-56-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Correlation of teratogenicity and molecular structure: ethylenethiourea and related compounds
- Author:
- Ruddick, J.A.
- Year:
- 1 976
- Bibliographic source:
- Teratology, 13:263–266.
- Reference Type:
- secondary source
- Title:
- Thiourea
- Author:
- Ziegler-Skylakakis, K.
- Year:
- 2 003
- Bibliographic source:
- Concise international chemical assessment document 49, World Health Organization, International Programme on Chemical Safety (IPCS), Geneva
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Administration of the test item to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg bw.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Thiourea
- EC Number:
- 200-543-5
- EC Name:
- Thiourea
- Cas Number:
- 62-56-6
- Molecular formula:
- CH4N2S
- IUPAC Name:
- thiourea
- Test material form:
- solid: particulate/powder
Constituent 1
Administration / exposure
- Route of administration:
- not specified
- Analytical verification of doses or concentrations:
- not specified
Doses / concentrations
- Dose / conc.:
- 480 mg/kg bw/day (nominal)
- Remarks:
- single dose
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Effect levels (maternal animals)
- Dose descriptor:
- NOEL
- Effect level:
- 480 mg/kg bw/day (nominal)
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Effect levels (fetuses)
- Dose descriptor:
- NOEL
- Effect level:
- 480 mg/kg bw/day (nominal)
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Thiourea had neither a maternally toxic nor a teratogenic effect when administered to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg body weight.
- Executive summary:
Thiourea had neither a maternally toxic nor a teratogenic effect when administered to rats on the 12th or 13th day of gestation as a single oral dose of 480 mg/kg body weight.
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