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EC number: 200-543-5
CAS number: 62-56-6
The test item thiourea was investigated for its potential to induce gene mutations according to the plate incorporation test (experiment I) and the pre-incubation test (experiment II) using Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and tester strain E. coli WP2 uvrA (pKM101).In two independent experiments several concentrations of the test item were used. Each assay was conducted with and without metabolic activation. The concentrations, including the controls, were tested in triplicate. The following concentrations of the test item were prepared and used in the experiments:31.6, 100, 316, 1000, 2500 and 5000 μg/plateNo precipitation of the test item was observed in any tester strain used in experiment I and II (with and without metabolic activation). In experiment I toxic effects of the test item were noted in tester strain TA1537 at a concentration of 5000 μg/plate (with metabolic activation). No further toxic effects of the test item were observed. No biologically relevant increases in revertant colony numbers of any of the five tester strains were observed following treatment with Thiourea at any concentration level, neither in the presence nor absence of metabolic activation in experiment I and II.
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