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EC number: 200-543-5
CAS number: 62-56-6
The pks-value is not determinable because Thiocarbamide forms no OH´ or
The dissociation constant of Thiocarbamide was determined according to
OECD guideline no. 112 with the titration method at 24°C.
The pks-value was not determinable because Thiocarbamide forms no OH´ or
no detailled information on results -> handbook data
According the CRC Handbook of Chemistry and physics the dissociation
contant of thiourea at 25°C is pKa = -1.
There are two different sources of information
available which are used in a weight-of-evidence approach.
In the CRC Handbook of Chemistry and Physics the
dissociation constant of thiourea at 25 °C is stated to be pKa = –1.
Data on the determination dissociation constant according OECD guideline
112 of the sponsor showed that pka-value is not determinable because
Thiourea forms no OH or H ions.
According the CRC Handbook of Chemistry and physics
the dissociation constant of thiourea at 25 °C is pKa = –1.
In another study provided by the sponsor the
dissociation constant of Thiourea was determined according to OECD
guideline no. 112 with the titration method at 24 °C. It was shown that
the pka-value was not determinable because Thiourea forms no OH or H
ions. This study is chosen as key value as an experimental result has a
higher reliability than handbook data.
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