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EC number: 200-543-5
CAS number: 62-56-6
No mortality or abnormalities of condition or behaviour, attributable to treatment were observed in any of the animals during the exposure period.
Table 1: Average body weights of groups of 5 rats
Treatment/kg body weight
Average body weight +/- SD
2x5mL distilled water
2x5 mL 7% Thioharnstoff
Table 2: Mean numbers of micronucleated erythrocytes and percentage polychromatic erythrocytes in bone marrow of rats
Incidence of micronucleated cells per 2000 erythrocytes per rat
Percentage polychromatic erythrocytes +/-SD
In a Wistar rats bone marrow micronucleus assay, 5 male and 5 female
animals per dose were treated by oral gavage with Thiourea (7 % a.i.) at
doses of 0 and 350 mg/kg bw. Bone marrow cells were harvested at 6 hours
post-treatment. The vehicle was water. There were no signs of toxicity
during the study. Thiourea was tested at an adequate dose based on the
results of an oral acute toxicity test. The positive control induced the
appropriate response. There was not a significant increase in the
frequency of micronucleated polychromatic erythrocytes in bone marrow
after any treatment time. This study is classified as acceptable. This
study satisfies the requirement for Test Guideline OECD 474 for in vivo
cytogenetic mutagenicity data.
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