Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-543-5 | CAS number: 62-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-10-17 to 1979-10-31
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Thiourea
- EC Number:
- 200-543-5
- EC Name:
- Thiourea
- Cas Number:
- 62-56-6
- Molecular formula:
- CH4N2S
- IUPAC Name:
- thiourea
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: SPF-reared (Cpb; WU, Wistar random)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Central insitute for the breeding of laboratory animals TNO, Zeist, The Netherlands
- Age at study initiation: No data
- Weight at study initiation: females mean weight: 142 g; males mean weight: 175 g
- Fasting period before study: No data
- Housing: Groupwise (5 per cage)
- Diet: Ad libitum (during exposure no access to food)
- Water: Ad libitum(during exposure no access to water)
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 1°C
- Humidity (%): 50-60%
Administration / exposure
- Route of administration:
- other: dispersion of 10 % thiourea to a fine mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 1.5 m³
- Method of holding animals in test chamber: Individually in wire-screen cages to prevent crowding and minimize filtration of the inspired air by animals fur
- Source and rate of air: Airflow rate of nebulizer: 0.9 m³/h; the mist was passed through the exposure chamber with a total airflow of 1.1 m³/h
- System of generating particulates/aerosols: Stainless steel/glass aerodynamic nozzle nebulizer
- Method of particle size determination: Particle Size determination with cascade Impactor (aerosol diameter < 3.3 µm)
TEST ATMOSPHERE
- Brief description of analytical method used: Gravimetrically by passing a measured quantity of the test atmosphere through a Cambridge glass fibre filter;
- Samples taken from breathing zone: No
VEHICLE
- Composition of vehicle: Water
- Concentration of test material in vehicle: 10 % solution
- Justification of choice of vehicle: Substance was provided by the sponsor as a 10 % solution in water
TEST ATMOSPHERE
- Particle size distribution: 100 % of particle counts have a diameter of less than 3.3 µm
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): No data - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically; Cambridge glass fibre filter
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 10 % solution
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequently (body weight determination at day 0, 1, 2, 4, 7 and 14)
- Necropsy of survivors performed: No
- Other examinations performed: Clinical signs, body weight - Statistics:
- No statistics
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 195 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: highest attainable concentration
- Mortality:
- One male died on the first day of the observation period.
- Clinical signs:
- other: During the first 30 min restlessness; thereafter motionless, eyes half-closed; after exposure the rats were slow in their movement, but otherwise looked normal.
- Body weight:
- During first day both males and females lost body weight; thereafter body weight gain again.
- Gross pathology:
- None
- Other findings:
- None
Any other information on results incl. tables
Table 1: Individual and mean body weights (g) of rats exposed to an aerosol of a 10 % solution of “Thioharnstoff” in rats
Animal code earmarks | 01) | 1 | 2 | 4 | 7 | 14 |
Males | ||||||
Z | 176 | - | - | - | - | - |
R1 | 176 | 167 | 171 | 183 | 190 | 226 |
R2 | 166 | 156 | 163 | 172 | 182 | 208 |
L1 | 180 | 173 | 176 | 186 | 196 | 218 |
L2 | 176 | 169 | 172 | 182 | 198 | 232 |
Mean body weight | 175 | 166 | 171 | 181 | 192 | 221 |
Females | ||||||
Z | 140 | 130 | 129 | --2) | 140 | 149 |
R1 | 148 | 141 | 143 | -- | 152 | 163 |
R2 | 130 | 126 | 130 | -- | 139 | 152 |
L1 | 142 | 133 | 132 | -- | 144 | 156 |
L2 | 149 | 143 | 143 | -- | 151 | 161 |
Mean body weight | 142 | 135 | 135 | -- | 145 | 156 |
1) Day 0: day of exposure
2) data omitted because unreliable
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The 4 h LC50 of thiourea in rats was higher than 195 mg/m³ air. Higher concentrations could not be attained.
- Executive summary:
In an acute inhalation toxicity study one dose group (5 males, 5 females) of SPF-reared rats (Cpb; WU, Wistar random) were exposed (whole body) to a fine mist of 10 % thiourea in water for 4 hours. Animals were then observed for 14 days.
One male died on the first day of the observation period. During the first 30 min restlessness was observed. Thereafter the rats were motionless and their eyes were half-closed. After the exposure the rats were slow in their movement, but otherwise looked normal.
The LC50 was determined to be higher than 195 mg/m³ (maximum attainable concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
Esta web utiliza cookies para mejorar su experiencia de navegación en nuestros sitios web.