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EC number: 200-543-5 | CAS number: 62-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Thiourea
- EC Number:
- 200-543-5
- EC Name:
- Thiourea
- Cas Number:
- 62-56-6
- Molecular formula:
- CH4N2S
- IUPAC Name:
- thiourea
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: Young adults
- Weight at study initiation: 2.5 to 3.08 kg
- Fasting period before study: No
- Housing: Individually
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 °C
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 10 % of total body area
- % coverage: 10 %
- Type of wrap if used: Thin layer of cellulose sheet wrapped in polyethylene foil
REMOVAL OF TEST SUBSTANCE
- Washing: The test substance was removed from the skin with water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 9 mL/kg body weight
- Constant volume or concentration used: Yes (constant volume: 9 mL/kg body weight)
VEHICLE
- Amount applied: The test substance was applied as solution in water (9 mL/kg) - Duration of exposure:
- 24 h
- Doses:
- 0, 1.0, 2.0 and 2.8 g/kg body weight
- No. of animals per sex per dose:
- 2 animals per sex and dose (altogether 8 males and 8 females)
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At day 0, and at the end of week 1 and 2
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, microscopic pathology (treated skin, liver, heart, kidneys), food consumption, water intake, body weights, haematological data, autopsy, histological examination of fixed organs (heart, liver, kidney, spleen). - Statistics:
- none
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: Slight erythema of the skin of rabbits treated with 2000 or 2800 mg/kg
- Gross pathology:
- No gross changes that could be related to the treating
- Other findings:
- None
Any other information on results incl. tables
Table 1: Individual body weights of male and female rabbits after a single dermal application of thiourea
Animal number and sex | Dose g/kg | Condition of skin | Body weights (in kg) | ||
At day 0 | At the end of week 1 | At the end of week 2 | |||
6336 M | 0 | Abraded | 3.08 | 3.00 | 3.24 |
6338 M | 0 | Intact | 2.80 | 2.83 | 2.93 |
6348 F | 0 | Abraded | 2.83 | 2.82 | 3.00 |
6352 F | 0 | Intact | 2.50 | 2.57 | 2.84 |
6337 M | 1 | Abraded | 3.07 | 2.96 | 3.24 |
6343 M | 1 | Intact | 2.84 | 2.85 | 2.97 |
6346 F | 1 | Abraded | 2.6 | 2.35 | 2.50 |
6353 F | 1 | Intact | 2.78 | 2.55 | 2.90 |
6340 M | 2 | Abraded | 2.81 | 2.73 | 2.88 |
6341 M | 2 | Intact | 3.05 | 3.04 | 3.12 |
6349 F | 2 | Abraded | 2.66 | 2.68 | 2.94 |
6351 F | 2 | Intact | 2.75 | 2.35 | 2.78 |
6334 M | 2.8 | Abraded | 2.93 | 2.94 | 3.04 |
6339 M | 2.8 | Intact | 2.88 | 2.86 | 3.00 |
6345 F | 2.8 | Abraded | 2.70 | 2.60 | 2.91 |
6350 F | 2.8 | Intact | 2.70 | 2.43 | 2.70 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Thiourea is practically non-toxic in rabbits, when applied dermally at a single dose of up to 2.800 mg/kg.
- Executive summary:
In an acute dermal toxicity study, groups of young adult New Zealand White albino rabbits (8/sex) were dermally exposed to thiourea in water for 24 hours, covering 10 % of body surface area at doses of 0, 1000, 2000 and 2800 mg/kg bw. Animals were subsequently observed for 14 days. No mortality occured at the highest dose of 2800 mg/kg bw.
Thiourea is practically non-toxic when applied in a single dose to the skin of rabbits.
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