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Partition coefficient

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Description of key information

There are three literature sources available. All results indicate that the partition coefficient is low. In the key study the partition coefficient (n-octanol/water) of thiourea was determined to be 0.12 (log Pow: -0.92) at 20 ± 1 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

Three literature sources are available reporting the partition coefficient of thiourea.

In a guideline study the partition-coefficient was determined according OECD guideline 107 with the shake flask method. The measurements were conducted at 20°C ± 1 °C and resulted in a partition coefficient of 0.12 (log Pow: –0.92) (Cardinaals, J.M., 1988).

According to the HSDB (hazardous substances databank), citing Govers et al. (1986) the partition coefficient of thiourea is –1.08 (log Kow).

According to the study report of Kotzias in "Überprüfung der Durchführbarkeit von Prüfungsvorschriften und der Aussagekraft der Grundprüfung des E. Chem. G. - Verteilungskoeffizient" the partition coefficient log Pow of thiourea is -1.61 (Korte and Greim, 1981).

The most reliable result, the determination of the partition coefficient according to OECD 107 was chosen as key value. Therefore the partition coefficient of thiourea is: logPow = –0.92 at 20°C ± 1 °C.