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EC number: 200-543-5
CAS number: 62-56-6
Table 3: Individual measurements of the partition
coefficient (n-octanol/water). Temperature of measurement 20+/-1°C.
Concentration after equilibrium
Total amount after equilibrium
Calculated partition coefficient
Mean partition coefficient
Octanol stock solution*
Relative standard deviation:
concentration of the test substance in n-octanol stock solution: 802.6
µg/ml (after UV analysis)
The partition coefficient (n-octanol/water) for
thiourea was determined according to the OECD guideline for testing of
chemicals number 107 (May 1981) and the EC method A.8, EEC Directive
84/449, Part L251 (September 1984) with the shake flask method. The
measurements were conducted at 20°C +/- 1°C and resulted in a partition
coefficient of 0.12 (log Pow: -0.92).
The study was performed in compliance with good
laboratory practice (GLP).
There are three literature sources available. All
results indicate that the partition coefficient is low.
In the key study the partition coefficient
(n-octanol/water) of thiourea was determined to be 0.12 (log Pow: -0.92)
at 20 ± 1 °C.
Three literature sources are available
reporting the partition coefficient of thiourea.
In a guideline study the
partition-coefficient was determined according OECD guideline 107 with
the shake flask method. The measurements were conducted at 20°C ± 1 °C
and resulted in a partition coefficient of 0.12 (log Pow: –0.92)
(Cardinaals, J.M., 1988).
According to the HSDB (hazardous substances
databank), citing Govers et al. (1986) the partition coefficient of
thiourea is –1.08 (log Kow).
According to the study report of Kotzias in
"Überprüfung der Durchführbarkeit von Prüfungsvorschriften und der
Aussagekraft der Grundprüfung des E. Chem. G. - Verteilungskoeffizient"
the partition coefficient log Pow of thiourea is -1.61 (Korte and Greim,
The most reliable result, the determination
of the partition coefficient according to OECD 107 was chosen as key
value. Therefore the partition coefficient of thiourea is: logPow =
–0.92 at 20°C ± 1 °C.
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