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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

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Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
other: OECD Guideline A-79.74 D
GLP compliance:
no
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
No details reported.
Buffers:
- pH 1.2: HCl, KCl
- pH 3,0: HCl/Citrate
- pH 7: Phopsphat/NaOH
- pH 9,0: Borate/NaOH
- all buffers at a concentration of 0.02 M
- all buffers were fumigated with nitrogen to avoid oxidative dagradation
Details on test conditions:
No details reported.
Number of replicates:
No details reported
Positive controls:
not specified
Negative controls:
not specified
Statistical methods:
No data.
Preliminary study:
Preliminary study performed
Test performance:
Not applicable.
Transformation products:
not measured
Details on hydrolysis and appearance of transformation product(s):
Not applicable.
Key result
Remarks on result:
hydrolytically stable based on preliminary test
Other kinetic parameters:
Thiourea does not hydrolyse.
Details on results:
Thiourea does not hydrolyse at pH 1.2, 3, 7, or 9.
Validity criteria fulfilled:
not applicable
Conclusions:
Thiourea is not susceptible to hydrolysis at environmentally relevant pH.
Executive summary:

The hydrolysis of thiourea was determined at pH 1.2, 3, 7, and 9 according to OECD Guideline A-79.74D at the concentration of maximum water solubility. The concentration of the parent substance in the test vessels was measured by means of UV spectroscopy. Under the conditions of the test no hydrolysis was observed.

The results are used in the assessment of the intirnsic properties of thiourea in a weight-of-evidence approach.

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
according to guideline
Guideline:
other: no guideline reported
Principles of method if other than guideline:
Not reported, secondary literature.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Details on sampling:
No details reported, secondary literature.
Buffers:
No details reported, secondary literature.
Details on test conditions:
No details reported, secondary literature.
Number of replicates:
No details reported, secondary literature.
Positive controls:
not specified
Negative controls:
not specified
Statistical methods:
No details reported, secondary literature.
Preliminary study:
No details reported, secondary literature.
Test performance:
No details reported, secondary literature.
Transformation products:
no
Details on hydrolysis and appearance of transformation product(s):
No details reported, secondary literature.
Key result
pH:
4
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Remarks on result:
hydrolytically stable based on preliminary test
Details on results:
No details reported, secondary literature.
Validity criteria fulfilled:
not specified
Conclusions:
Thiourea is stable to hydrolysis at pH 4, 7, and 9.
Executive summary:

Thiourea is reported to be stable to hydrolysis at pH 4, 7, and 9.

Details on test method, analytical methods, and test duration are not available (secondary literature).

The results are used in the assessment of the intirnsic properties of thiourea in a weight-of-evidence approach.

Description of key information

Thiourea is not susceptible to hydrolysis at environmentally relevant pH. 

Key value for chemical safety assessment

Additional information

Two data sources are available that describe the hydrolysis of thiourea at different pH. Both data sources are of low reliability. However, as no other reliable standard data are available, and as both sources report the same result, the data are used in an weight-of-evidence approach:

Schmidt-Bleek et al. (1982) report that thiourea is stable to hydrolysis at pH 4, 7, and 9.

Details on test method, analytical methods, and test duration are not available (secondary literature).

Korte & Greim (1981) determined the hydrolysis of thiourea at pH 1.2, 3, 7, and 9 according to OECD Guideline A-79.74D at the concentration of maximum water solubility. The concentration of the parent substance in the test vessels was measured by means of UV spectroscopy. Under the conditions of the test no hydrolysis was observed.