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Diss Factsheets
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EC number: 200-543-5 | CAS number: 62-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline A-79.74 D
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- No details reported.
- Buffers:
- - pH 1.2: HCl, KCl
- pH 3,0: HCl/Citrate
- pH 7: Phopsphat/NaOH
- pH 9,0: Borate/NaOH
- all buffers at a concentration of 0.02 M
- all buffers were fumigated with nitrogen to avoid oxidative dagradation - Details on test conditions:
- No details reported.
- Number of replicates:
- No details reported
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- No data.
- Preliminary study:
- Preliminary study performed
- Test performance:
- Not applicable.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- Not applicable.
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Other kinetic parameters:
- Thiourea does not hydrolyse.
- Details on results:
- Thiourea does not hydrolyse at pH 1.2, 3, 7, or 9.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Thiourea is not susceptible to hydrolysis at environmentally relevant pH.
- Executive summary:
The hydrolysis of thiourea was determined at pH 1.2, 3, 7, and 9 according to OECD Guideline A-79.74D at the concentration of maximum water solubility. The concentration of the parent substance in the test vessels was measured by means of UV spectroscopy. Under the conditions of the test no hydrolysis was observed.
The results are used in the assessment of the intirnsic properties of thiourea in a weight-of-evidence approach.
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- Not reported, secondary literature.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- No details reported, secondary literature.
- Buffers:
- No details reported, secondary literature.
- Details on test conditions:
- No details reported, secondary literature.
- Number of replicates:
- No details reported, secondary literature.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- No details reported, secondary literature.
- Preliminary study:
- No details reported, secondary literature.
- Test performance:
- No details reported, secondary literature.
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- No details reported, secondary literature.
- Key result
- pH:
- 4
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- No details reported, secondary literature.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Thiourea is stable to hydrolysis at pH 4, 7, and 9.
- Executive summary:
Thiourea is reported to be stable to hydrolysis at pH 4, 7, and 9.
Details on test method, analytical methods, and test duration are not available (secondary literature).
The results are used in the assessment of the intirnsic properties of thiourea in a weight-of-evidence approach.
Referenceopen allclose all
Description of key information
Thiourea is not susceptible to hydrolysis at environmentally relevant pH.
Key value for chemical safety assessment
Additional information
Two data sources are available that describe the hydrolysis of thiourea at different pH. Both data sources are of low reliability. However, as no other reliable standard data are available, and as both sources report the same result, the data are used in an weight-of-evidence approach:
Schmidt-Bleek et al. (1982) report that thiourea is stable to hydrolysis at pH 4, 7, and 9.
Details on test method, analytical methods, and test duration are not available (secondary literature).
Korte & Greim (1981) determined the hydrolysis of thiourea at pH 1.2, 3, 7, and 9 according to OECD Guideline A-79.74D at the concentration of maximum water solubility. The concentration of the parent substance in the test vessels was measured by means of UV spectroscopy. Under the conditions of the test no hydrolysis was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.