Registration Dossier
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EC number: 200-543-5 | CAS number: 62-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: abstract
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 963
- Reference Type:
- secondary source
- Title:
- Thiourea
- Author:
- Ziegler-Skylakakis, K.
- Year:
- 2 003
- Bibliographic source:
- Concise international chemical assessment document 49, World Health Organization, International Programme on Chemical Safety (IPCS), Geneva
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Measurement of the radioactivity in fluids and tissues, paper chromatographic analysis of the chemical state of the S35, and histologic localization of the S35 by radioautography.
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- not specified
- Radiolabelling:
- yes
- Remarks:
- S35
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
Results and discussion
Main ADME results
- Type:
- distribution
- Results:
- Rapid passage of thiourea from the mother to the fetus occurred. The fetal serum concentration was lower than that of the maternal serum.
Any other information on results incl. tables
The metabolism of thiourea S35 by the developing fetal rat was studied by measurement of the radioactivity in fluids and tissues, paper chromatographic analysis of the chemical state of the S35, and histologic localization of the S35 by radioautography. Rapid passage of the thiourea from the mother to the fetus occurred. In older embryos, at 12 and 24 hr after the administration of thiourea the amniotic fluid concentration was higher than that in the maternal serum. The fetal serum concentration was lower than that of the maternal serum. The fetal thyroid to fetal serum concentration ratio began increasing on the 17th day, and by the 20th day it was 9.3 as compared with 24 for the mother. The time of appearance of the concentrating ability for thiourea S35 coincides with that for I131. The S35 was predominantly present as thiourea in the serum, amniotic fluid and urine, but some protein-bound material was also found in liver tissues, serum and amniotic fluid. Both fetal and maternal thyroid tissue had increased amounts of S3S as either sulfate or thiosulfate. The radioautographs showed concentration of grains over thyroid cells and colloid at 3 hr, but after 12 and 24 hr most of the activity was over the colloid. Some concentration of S36 was observed in fetal tracheal cartilage and in the tubules of the maternal kidney
Applicant's summary and conclusion
- Conclusions:
- Rapid passage of thiourea from the mother to the fetus occurred. The fetal serum concentration was lower than that of the maternal serum.
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