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EC number: 200-543-5
CAS number: 62-56-6
Table 1: Individual and average skin irritation scores of undiluted thiourea
In a primary dermal irritation study 12 healthy, adult New Zealand White albino rabbits were dermally exposed to 0.5 g of undiluted thiourea on 1 inch² of the body surface area on the back of the animals. Test sites were covered with an occlusive dressing for 24 hours. Animals were then observed for 72 hours. Irritation was scored by the method of Draize (1944) and the CIVO grading system. After 24 hours dermal effects were observed in seven out of twelve rabbits. These effects consisted of very slight to well-defined erythema with or without very slight or slight oedema. After 72 hours one rabbit treated on the abraded skin showed slight scaliness. No other dermal effects were observed. In this study, thiourea is very slightly to slightly irritatin but not relevant for classification.
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