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EC number: 200-543-5
CAS number: 62-56-6
Table 1: Individual and average skin irritation scores of undiluted
In a primary dermal irritation study 12
healthy, adult New Zealand White albino rabbits were dermally exposed to
0.5 g of undiluted thiourea on 1 inch² of the body surface area on the
back of the animals. Test sites were covered with an occlusive dressing
for 24 hours. Animals were then observed for 72 hours. Irritation was
scored by the method of Draize (1944) and the CIVO grading system. After
24 hours dermal effects were observed in seven out of twelve rabbits.
These effects consisted of very slight to well-defined erythema with or
without very slight or slight oedema. After 72 hours one rabbit treated
on the abraded skin showed slight scaliness. No other dermal effects
were observed. In this study, thiourea is very slightly to slightly
irritatin but not relevant for classification.
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