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EC number: 200-543-5
CAS number: 62-56-6
Adult male rats treated with a lethal edematogenic dose of thiourea (TU)
(10.0 mg/kg, intraperitoneally) responded with significant elevations in
plasma histamine, lung vascular permeability and 100% mortality over a
subsequent 24-h period. When rats were pretreated with a small
non-lethal dose of TU (0.5 mg/kg) and subsequently challenged with the
lethal dose at 1, 4, 8, 16 and 32 days later, there was complete
protection against death for at least 8 days and partial protection for
an additional 24 days. This decrease in mortality correlated quite
closely with reduced plasma histamine levels and diminished pulmonary
vascular permeability. The results suggest that reduced exposure of the
pulmonary vasculature to histamine may offer a partial explanation for
tolerance to thiocarbamide compounds in the rat.
Thiourea was administered to male Sprague-Dawley rats at a dose of 10
mg/kg bw. intraperitoneally. This resulted in 100 % mortality within 24
h. When rats were pretreated with a small non-lethal dose of thiourea
(0.5 mg/kg) and subsequently challenged with the lethal dose at 1, 4, 8,
16 and 32 days later, there was complete protection against death for at
least 8 days and partial protection for an additional 24 days. Therefore
it was concluded that the decrease in mortality correlated quite closely
with reduced plasma histamine levels and diminished pulmonary vascular
permeability. The authors concluded that the degree of tolerance to
thiourea developed is related to plasma histamine concentration and
pulmonary vascular permeability.
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