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EC number: 200-543-5
CAS number: 62-56-6
Table 1: The mean values SEM of body weights (kg) of control and hypothyroid lambs
Control group (kg)
Treated group (kg)
22.00 ± 0.20
** Highly significant at P < 0.01
Eight male lambs aged 3 to 3.5 months were orally administered 50 mg
thiourea/kg body weight daily for 3.5 months. There were four control
lambs. Hypothyroidism was caused by thiourea adminsitration and which
led to retardation of growth and interfered with the sexual maturity of
the growing male lambs. The treated males did not show any sexual desire
when introduced to ewes in estrus compared with control animals.
Palpation of the testes of treated lambs revealed hydrocoele with small
testes. The average weight of the testes of the hypothyroid lambs was
significantly reduced (3.2 ± 0.255 g) compared with that of control
lambs (8.9 ± 1.00 g). The testes showed underdeveloped, small, empty
seminiferous tubules with thick basement membranes. The Sertoli cells
were primitive and nonfunctional. The level of testosterone in the
plasma of these hypothyroid lambs was not detectable. The results of
this publication are summarized in the " Concise International Chemical
assessment Document 49 - Thiourea" (WHO, 2003).
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