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EC number: 200-543-5
CAS number: 62-56-6
No effects were reported after examination of the eyes following the
In a primary eye irritation study similar to the OECD guideline 405, 100
mg Thiourea were instilled undiluted without any vehicle into the
conjunctival sac of the left eye of 6 male Himalayan rabbits. The eye
lids were kept close for 1 second and the application lasted during the
whole observation period for 72 hours as the eyes were not washed after
application. Animals were observed immediately after application, and 1,
24 and 72 hours after the treatment. Irritation was scored according to
Draize et al. (1944). Fluorescein was used to assess the score. The
right eye in which 0.1 ml isotonic NaCl were instilled served as control.
A deficiency of the study is that there is no detailled documentation of
individual animal data. Due to the fact that thiourea is not considered
to be irritating in this eye irritation test and the detailled
description of the procedure of the test this fact can be neglected.
The scores were reported as mean. Thiourea is reported to be not
irritating to the eye. Nevertheless a with respect to the conjunctiva an
irritation score of 1-2 has been reported for swelling and redness.
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