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EC number: 205-087-0
CAS number: 133-06-2
Inhalation of captan may form a route of human exposure. The purpose of
this study was to assess the sub-chronic inhalation toxicity of captan,
following exposure to rats for 13 weeks (5 exposures/week) to determine
effect and no-effect levels. Satellite groups were attached to the
control and highest exposure groups and were retained after the last
exposure for a 4-week observation period.
The rat was chosen since there is considerable general and toxicologlcal
data available to assist in the interpretation of results. The
Alpk:APfSD strain was used in the study since relevant background data
were available. Groups of 10 male and 10 female AlpK:APfSD rats were
exposed nose-only to target concentrations of 0.1, 0.5 or 5.0 µg/l
captan, and 20 male and 20 female rats were exposed to 15.0 µg/l captan,
for 6 hours per day, 5 days per week for 13 weeks. A concurrent control
group of 20 male and 20 female rats was similarly treated but was
exposed to air only. Ten males and 10 females from each group were
killed in week 14 following their last exposure, and the remaining
animals were killed in week 18 following a 4-week 'recovery' phase.
The mean atmospheric concentrations of captan throughout the study,
analysed by gas chromatography were 0.13, 0.60, 5.06 and 12.98 µg/l. The
test atmospheres had study mean mass median aerodynamic diameters of
0.95, 1.22, 1.57 and l.60 µm respectively for the 0.13, 0.60, 5.06 and
12.98 µg/l captan exposure levels and respective geometric standard
deviations of 1.82, 1.80, 1.84 and 2.00.
No treatment-related changes were seen in ophthalmoscopy, clinical
chemistry or haematological parameters in any exposed group. No evidence
of kidney toxicity was seen in this study. Treatment-related effects
were confined to the respiratory tract, were consistent with exposure to
an irritant particulate and affects in the lung were considered
responsible for five male mortalities during the study in the group
exposed to 12.98 µg/l captan. Lungs from animals allowed to recover for
4weeks were completely normal. 0.60 µg/l captan is considered to be a
no-effect level for the lung. The larynx was the only other organ to be
affected. Effects considered to be of toxicological significance were
seen at 12.98 and 5.06 µg/l. Effects considered to be an adaptive
response to irritants were seen at the lower concentration. The
toxicological no-effect level for inhalation (NOEL) for captan was
considered to be 0.60 µg/l.
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