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EC number: 205-087-0 | CAS number: 133-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
- Carcinogenicity
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- Specific investigations
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- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-11-12 to 2014-12-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material: Captan, N-(trichloromethylthio)cyclohex-4-ene-1,2-dicarboximide
- Molecular formula: C9H8Cl3NO2S- Cass No.: 133-06-2
- Molecular mass: 300.59
- Physical state: white solid
- Date of arrival: 29 January and 4 Feburary 2002
RADIOLABELLED TEST SUBSTANCE
- Test Item: CAPTAN, [carboximide-14C]
- Chemical name: 2-[(Trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
- Molecular formula: C9H8Cl3NO2S
- Specific activity: 5.11 MBq/mg corresponding to 41.68 mCi/mmol
- Source: ADAMA MAKHTESHIM LTD.
- Batch number: XXI/58/A/2
- Radiochemical purity: 93.46 %
- Chemical purity 92.13 %
- Storage: Below -18 °C
NON RADIOLABELLED TEST SUBSTANCE
- Test item: Captan
- Sum formula (A.I.): C9H8Cl3NO2S
- Appearance: Solid, Off-white powder
- Source: ADAMA MAKHTESHIM LTD.
- Batch number: 93138112
- Purity: 94.3 %
- Storage: Keep locked up and keep the container tightly closed, protected from light in a dry, cool and well-ventilated place in the original container.
- Expiry date: 2015-02-16
- Test system: Inoculum of the aqueous phase of non-adapted activated sludge
- Source: Municipal sewage treatment plant. 31137 Hildesheim. Germany- Receipt: 2014-11-07 - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 738 g/L
- Based on:
- test mat.
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 13
- St. dev.:
- 5
- Sampling time:
- 28 d
- Details on results:
- In the toxicity control containing both test and reference item a biodegradation of 46 % (related to Aniline) was determined within 14 days and it came to 72 % after 28 days. The biodegradation of the reference item was not inhibited by the test item in the toxicity control. Furthermore the solvent acetonitrile didn’t impact the degradation of Aniline sulphate, [14C(U)]-.The biodegradation of the test item (look at attached graphic, Figure 1) in comparison to the readily degradable functional control and the toxicity control. The mean 10 % level (beginning of biodegradation) was reached after a long-lasting adaptation phase on day 19. The biodegradation increased only slowly within the further course of the study and the 60 % pass level was not reached until test end. The mean biodegradation after 28 days was 13 %.Under the test conditions the test item is classified as not readily biodegradable in the 10-day-window and within 28 days.
- Validity criteria fulfilled:
- yes
- Remarks:
- Degradation of the functional control reached the pass level of ≥ 60 % after 12 days. Differences of extremes of replicate values of removal of the test item at the end of the test was less than 20 %.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Substance is not readily biodegradable
- Executive summary:
The ready biodegradability of captan, [carboximide-14C] was determined with a non-adapted activated sludge over a test period of 28 days in the Modified Sturm Test. The mean biodegradation after 28 days was 13 %.
Substance is not readily biodegradable
Reference
Table 5.2.1-1: CO2-Production (as total radioactivity) and Biodegradation in the test item vessels
Study day |
Date |
Test item |
|||||
Replicate 1 |
Replicate 2 |
||||||
[kBq/1.8 L] |
Degradation [%] |
[kBq/1.8 L] |
Degradation [%] |
||||
Gross Sum |
Net Sum |
Gross Sum |
Net Sum |
||||
1 |
2014-11-13 |
0.3 |
0.3 |
0 |
0.3 |
0.3 |
0 |
2 |
2014-11-14 |
1.1 |
1.0 |
0 |
1.0 |
1.0 |
0 |
5 |
2014-11-17 |
5.4 |
5.4 |
1 |
5.6 |
5.5 |
1 |
7 |
2014-11-19 |
10.2 |
10.2 |
1 |
13.6 |
13.5 |
1 |
9 |
2014-11-21 |
16.4 |
16.4 |
2 |
17.7 |
17.6 |
2 |
12 |
2014-11-24 |
22.6 |
22.5 |
2 |
21.7 |
21.6 |
2 |
14 |
2014-11-26 |
25.4 |
25.3 |
2 |
23.9 |
23.8 |
2 |
16 |
2014-11-28 |
27.9 |
27.9 |
3 |
25.9 |
25.8 |
2 |
19 |
2014-12-01 |
32.1 |
32.0 |
3 |
33.4 |
33.3 |
3 |
22 |
2014-12-04 |
39.4 |
39.3 |
4 |
40.3 |
40.2 |
4 |
26 |
2014-12-08 |
62.6 |
62.5 |
6 |
52.8 |
52.7 |
5 |
28 |
2014-12-10 |
87.5 |
87.4 |
8 |
60.6 |
60.5 |
6 |
29 |
2014-12-11 |
159.4 |
159.3 |
15 |
116.1 |
116.0 |
11 |
Description of key information
Not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Biodegradation for captan was determined by a CO2 evolution test according to OECD 301 B. Degradation of captan was very slow. The mean 10 % level was reached after a long-lasting adaptation phase on day 19. The biodegradation increased only slowly within the further course of the study and the 60 % pass level was not reached until test end. The mean biodegradation after 28 days was 13 %.
Captan is known to hydrolyse rapidly with half-life time DT50 (pH7) of 4.9 hours (Lee, K.S. 1989). Captan / its degradation products are assessed not to be ready biodegradable.
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